Cell death in biology and pathology

  • I. D. Bowen
  • R. A. Lockshin

Table of contents

  1. Front Matter
    Pages i-xviii
  2. I. D. Bowen, R. A. Lockshin
    Pages 1-7
  3. J. R. Hinchliffe
    Pages 35-78
  4. Richard A. Lockshin
    Pages 79-121
  5. S. M. Hinsull, D. Bellamy
    Pages 123-144
  6. P. B. Gahan
    Pages 145-169
  7. N. A. Wright
    Pages 171-207
  8. Benjamin F. Trump, Irene K. Berezesky, Alvaro R. Osornio-Vargas
    Pages 209-242
  9. Leonard Hayflick
    Pages 243-285
  10. Richard A. Lockshin, Moira Royston, Michael Joesten, Timothy Carter
    Pages 287-293
  11. Allan Munck, Gerald R. Crabtree
    Pages 329-359
  12. Monica W. Ross, Robert S. Yamamoto, Gale A. Granger
    Pages 361-377
  13. I. D. Bowen
    Pages 379-444
  14. Back Matter
    Pages 445-493

About this book


It is clear that lysosomal enzymes often play a role in the destruction of the cytoplasm, but very few authorities feel that they initiate the process (Chapters 1, 2, 3, 5 -8, 12, 13). The cells show many forms of damage, and sometimes even complete destruction, before Iysosomes become a dominant part of the environ­ ment. What initiates the process is still unclear, although in several instances it appears that the death of a cell may arise from anyone of several pathways (Chapters, 10, II). It is rather interesting that evolution has chosen to achieve the same goal by different means. Apparently no one point is exceptionally or pre­ ferentially vulnerable, though a common pathway, such as permeability of the plasma membrane to calcium (Chapter 7), might currently be too subtle for routine identification. Factors which affect membrane stability and which induce mem­ brane bending can lead to blebing, cell fragmentation and death. Thus, more work on the changing chemistry of the plasma membrane in relation to environmental fluctuations would be welcomed. Space requirements and the major orientation of the book forced the exclusion of several very interesting topics: an evolutionary treatment of the advantages of cell death as a means of eliminating vestigial organs or embryonic scaffolding; or consider­ ation of the merits of body sculpting by cell death rather than cell growth.


DNA DNA repair biology cell cell cycle cell death enzyme evolution growth insects membrane morphology programmed cell death proteins tissue

Editors and affiliations

  • I. D. Bowen
    • 1
  • R. A. Lockshin
    • 2
  1. 1.Department of ZoologyUniversity CollegeCardiffUK
  2. 2.Department of Biological SciencesSt John’s UniversityNew YorkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1981
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6923-3
  • Online ISBN 978-94-011-6921-9
  • Buy this book on publisher's site