Problems of Birth Defects

From Hippocrates to Thalidomide and After

  • T. V. N. Persaud

Table of contents

  1. Front Matter
    Pages i-x
  2. Beliefs, Mythology, Magic And Superstition

    1. Front Matter
      Pages 1-4
    2. Papers 1 and 2

  3. Epidemiology of Birth Defects

  4. Teratological Mechanisms

    1. Front Matter
      Pages 71-74
    2. Papers 7

    3. Papers 8

    4. Papers 9

      1. James G. Wilson
        Pages 88-90
    5. Papers 10

  5. Cytogenetic and Chromosomal Studies

    1. Front Matter
      Pages 97-100
    2. Papers 11 and 12

    3. Papers 13

      1. Joe Hin Tjio, Albert Levan
        Pages 112-118
    4. Papers 14, 15 and 16

      1. G. A. Machin
        Pages 136-139
      2. Hyon J. Kim, Lillian Y. F. Hsu, Sophie Paciuc, Steluta Cristian, Alicia Quintana, Kurt Hirschhorn
        Pages 140-143
    5. Papers 17 and 18

      1. Rodrigo Guerrero, Oscar I. Rojas
        Pages 145-147
      2. C. J. Roberts, C. R. Lowe
        Pages 148-150
    6. Papers 19

      1. C. O. Carter
        Pages 152-157
    7. Papers 20

      1. David A. E. Shephard
        Pages 159-161
  6. Environmental Influences and Congenital Abnormalities

    1. Front Matter
      Pages 163-165
    2. Papers 21

      1. Fred Hale
        Pages 166-167
    3. Papers 22, 23 and 24

      1. Russell J. Blattner
        Pages 181-186
      2. Georges Desmonts, Jacques Couvreur
        Pages 187-193
    4. Papers 25

    5. Papers 26, 27, 28 and 29

    6. Papers 30, 31 and 32

      1. Arthur L. Herbst, Howard Ulfelder, David G. Poskanzer
        Pages 217-220
    7. Papers 33, 34 and 35

    8. Papers 36

    9. Papers 37 and 38

      1. Laman Amin-Zaki, Sami Elhassani, Mohamed A. Majeed, Thomas W. Clarkson, Richard A. Doherty, Michael Greenwood
        Pages 233-241
    10. Papers 39 and 40

    11. Papers 41

      1. Kenneth L. Jones, David W. Smith
        Pages 264-273
    12. Paper 42

      1. James H Renwick, Anne M Possamai, Madeleine R Munday
        Pages 275-279
    13. Papers 43 and 44

About this book


Surprisingly, the beginning of a modern approach This collection of articles and commentaries is an to the problems of birth defects is relatively recent integration of information from many disciplines, and dates from Gregg's classical report in 1941 that and presents a comprehensive survey of both recent mothers who contracted rubella during the first tri­ and previously reported work related to the major mester of pregnancy gave birth to infants with severe aspects of birth defects. In particular, an attempt multiple anomalies. For the first time, an environ­ has been made to provide a critical assessment of mental agent was found to be teratogenic in man current concepts and to identify areas in need of and was documented in a thoroughly convincing further investigation. manner. Since then, many important discoveries The scope of this volume and space limitations and significant developments have been made, par­ precluded discussion of and reference to all papers ticularly in the areas of environmental teratogenesis, of relevance or importance: a work of the present hereditary mechanisms, and prenatal diagnosis. nature must necessarily be selective. Some good In recent years, there has been an impressive papers have been left out or given relatively little surge of interest in the causes and prevention of consideration. It is my hope that the list of Further birth defects. Undoubtedly this resulted not only References will be consulted and should compensate from the thalidomide tragedy, but also from the for this lack of completeness.


development fetus newborn pregnancy

Editors and affiliations

  • T. V. N. Persaud
    • 1
    • 2
  1. 1.Teratology Research LaboratoryUniversity of ManitobaCanada
  2. 2.Health Sciences CentreWinnipegCanada

Bibliographic information