Intrinsic mutagenesis

A genetic approach to ageing

  • Authors
  • Macfarlane Burnet

Table of contents

  1. Front Matter
    Pages i-ix
  2. Mutation and the Concept of Intrinsic Mutagenesis

    1. Front Matter
      Pages 1-1
    2. Macfarlane Burnet
      Pages 3-9
    3. Macfarlane Burnet
      Pages 25-35
    4. Macfarlane Burnet
      Pages 36-45
  3. Physiology and Pathology of Ageing

    1. Front Matter
      Pages 47-47
    2. Macfarlane Burnet
      Pages 49-59
    3. Macfarlane Burnet
      Pages 60-77
    4. Macfarlane Burnet
      Pages 78-88
    5. Macfarlane Burnet
      Pages 89-101
    6. Macfarlane Burnet
      Pages 102-106
    7. Macfarlane Burnet
      Pages 107-124
  4. Malignant Disease

    1. Front Matter
      Pages 125-125
    2. Macfarlane Burnet
      Pages 127-144
    3. Macfarlane Burnet
      Pages 145-157
    4. Macfarlane Burnet
      Pages 158-169
  5. Other Age-associated Conditions

    1. Front Matter
      Pages 189-189
    2. Macfarlane Burnet
      Pages 191-204
  6. Back Matter
    Pages 227-244

About this book


This book is something which almost accidentally has developed very differently from how it was initially planned. The intention was to elaborate the part played by the immune system in ageing with the role of the thymus as central theme. It was to be essentially an expansion of a lecture I gave in 1970 and would inevitably have been concerned with much the same material as Walford's book, The Immunologic Theory of Aging, though from a different slant. What changed its character arose from a series of attempts to find logical connection between two findings that most gerontologists regard as axiomatic: that the lifespan of a mammal is genetically determined, and that the actual process of ageing is an accumulation of genetic error, of somatic mutations. It is possible that the connection is so indirect, circuitous and multiform that generations of detailed and unattractive research will be needed to elucidate it, or, more likely, the whole matter discarded as a non-problem. But a more inspiring approach does seem possible. The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.


ageing atherosclerosis bacteria biology brain cells genes genetics infection mutagen mutagenesis mutation pathology physiology thymus

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1974
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6608-9
  • Online ISBN 978-94-011-6606-5
  • Buy this book on publisher's site