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Immunological Aspects of Transplantation Surgery

  • Roy Y. Calne

Table of contents

  1. Front Matter
    Pages i-viii
  2. R. Y. Calne
    Pages 1-3
  3. B. M. Herbertson
    Pages 4-38
  4. P. I. Terasaki, G. Opelz, A. Ting
    Pages 92-111
  5. G. E. Striker, L. J. Quadracci, T. L. Marchioro
    Pages 136-152
  6. Frank P. Stuart
    Pages 191-213
  7. Dennis W. Jirsch, Erwin Diener
    Pages 214-259
  8. E. White
    Pages 260-278
  9. Robert J. Corry, Paul S. Russell
    Pages 279-295
  10. R. Y. Calne
    Pages 296-316
  11. Back Matter
    Pages 339-342

About this book

Introduction

R. Y.Calne Surgeons are transplanting kidneys in ever increasing numbers-more than 10000 renal allografts have now been reported to the Transplant Registry. With related donors 75% of grafted kidneys continued to function after 2 years, compared with 50% when the donors were unrelated. The therapeutic value is obvious, but the management is largely empirical and results have improved little in the past 5 years. The basic sciences related to tissue transplantation have advanced rapidly. New serological and tissue culture techniques and chemical analysis of antigens and anti­ bodies have produced complicated data that is almost incomprehensible to the non­ specialist. Mathematical treatment of genetic probabilities and of immunological kinetics are similarly difficult to follow for those not especially trained. There has always been a gulf between the practical clinician whose patients do not behave like inbred rodents and the biologist who likes carefully controlled experiments with easily observed results. Both realize, however, that predictable and safe control of rejection must involve close collaboration and co-operation between the laboratory and the clinic. Unfortwlately, the different nature of the work and the workers has widened the gap between them. The clinicians tend to improve their techniques and patient care, whilst the biologists seek clearer and more precisely deflned experi­ ments which lead them to use increasingly artiflcial experimental models.

Keywords

surgery transplantation

Editors and affiliations

  • Roy Y. Calne
    • 1
  1. 1.Department of SurgeryUniversity of CambridgeCambridgeEngland

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-6600-3
  • Copyright Information Springer Science+Business Media B.V. 1973
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6602-7
  • Online ISBN 978-94-011-6600-3
  • Buy this book on publisher's site