The Benzodiazepines

Use, overuse, misuse, abuse

  • John Marks

Table of contents

  1. Front Matter
    Pages i-ix
  2. Summary

    1. John Marks
      Pages 1-2
  3. Glossary

    1. John Marks
      Pages 3-4
  4. The general problem of dependence

    1. Front Matter
      Pages 5-5
    2. John Marks
      Pages 7-8
    3. John Marks
      Pages 13-15
  5. Benzodiazepine Dependence

  6. Significance of Benzodiazepine Dependence within the Community

    1. Front Matter
      Pages 47-47
    2. John Marks
      Pages 49-49
    3. John Marks
      Pages 51-57
    4. John Marks
      Pages 59-66
    5. John Marks
      Pages 67-70
    6. John Marks
      Pages 71-75
  7. Conclusions

    1. Front Matter
      Pages 77-77
    2. John Marks
      Pages 79-80
  8. Back Matter
    Pages 81-111

About this book


The story of the benzodiazepines is a fascinating one: the synthesis of a long series of inert compounds and the abandonment of the project: months later, the renewal of the project and the discovery that this compound R05-0690 (Librium ®) was a sedative and muscle relaxant in laboratory animals: the recognition that its postulated structure was wrong and that it was in fact a member of an entirely new chemical class: the excitement caused by the discovery of the powerful taming effect of the drug in wild animals: the even greater excitement in medical circles when its dramatic anxiety relieving effects were cstablished in humans: the subsequent enormous world­ wide usc of drugs of the benzodiazepine group. I have reason to know the story well for during that period I worked in various capacities in research, marketing and manage­ ment in the British subsidiary of F. Hoffmann-Ia Roche. It was during this period that I became interested in whether dependence on benzodiazepines could occur and if so to what extent, but felt that this could be examined best from outside the concern. Having now retired from Roche back to academic medicine I have taken the opportunity to examine and analyse the evidence.



Authors and affiliations

  • John Marks
    • 1
  1. 1.Medical StudiesGirton CollegeCambridgeUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1978
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6205-0
  • Online ISBN 978-94-011-6203-6
  • Buy this book on publisher's site