Rhesus haemolytic disease

Selected papers and extracts

  • Cyril A. Clarke

Table of contents

  1. Front Matter
    Pages v-xv
  2. Discovery of the Rh blood group system and related matters

    1. Front Matter
      Pages 1-1
    2. Ruth Renter Darrow
      Pages 3-37
    3. Philip Levine, Rufus E. Stetson
      Pages 39-40
    4. Philip Levine, Lyman Burnham, E. M. Katzin, Peter Vogel
      Pages 61-73
    5. Cyril A. Clarke
      Pages 78-79
    6. Alexander S. Wiener
      Pages 81-85
    7. R. R. A. Coombs, A. E. Mourant, R. R. Race
      Pages 88-88
    8. Cyril A. Clarke
      Pages 91-92
    9. A. S. Wiener
      Pages 93-93
    10. Alexander S. Wiener
      Pages 94-98
  3. Methods of treating the established disease

  4. Prophylaxis

    1. Front Matter
      Pages 127-127
    2. Enno Kleihauer, Hildegard Braun, Klaus Betke
      Pages 139-141
    3. Alvin Zipursky, Alan Hull, F. D. White, L. G. Israels
      Pages 143-145
    4. Cyril A. Clarke
      Pages 147-150
    5. Cyril A. Clarke
      Pages 151-152
    6. R. Finn, C. A. Clarke, W. T. A. Donohoe, R. B. McConnell, P. M. Sheppard, D. Lehane et al.
      Pages 153-158
    7. Kurt Stern, Maya Berger
      Pages 159-160
    8. Kurt Stern, Harold S. Goodman, Maya Berger
      Pages 161-169
    9. Vincent J. Freda, John G. Gorman
      Pages 171-175
    10. C. A. Clarke, W. T. A. Donohoe, R. B. McConnell, J. C. Woodrow, R. Finn, J. R. Krevans et al.
      Pages 191-197
    11. J. C. Woodrow, C. A. Clarke, W. T. A. Donohoe, R. Finn, R. B. McConnell, P. M. Sheppard et al.
      Pages 198-202
    12. W. Pollack, J. G. Gorman, V. J. Freda, W. Q. Ascari, A. E. Allen, W. J. Baker
      Pages 211-214
    13. P. L. Mollison, N. C. Hughes-Jones, Margaret Lindsay, Jane Wessely
      Pages 231-247
    14. Cyril A. Clarke
      Pages 249-252
    15. Alvin Zipursky, Lyonel G. Israels
      Pages 253-266
    16. Cyril A. Clarke
      Pages 267-269
    17. Cyril A. Clarke
      Pages 270-271
    18. W. Pollack, W. Q. Ascari, R. J. Kochesky, R. R. O’Connor, T. Y. Ho, D. Tripodi
      Pages 273-280
    19. J. C. Woodrow, C. A. Clarke, R. B. Mcconnell, Shona H. Towers, W. T. A. Donohoe
      Pages 285-288
    20. P. L. Mollison, S. L. Barron, C. C. Bowley, J. C. McClure Browne, Cyril Clarke, Richard Doll et al.
      Pages 289-294

About this book


Jaundice ofnewbom infants was described by several authors in the 17th century. The condition, however, was usually thought of as being similar to adult jaundice and due ro occlusion of the bile ducts by 'glutinous humours'. On the other hand, some writers reported on the fact that more than one consecutive baby was often affected, and there is a classic example of the disease in twins written by Louyse Bourgeois, the midwife of Marie de Medici, in 1609. It was not until early in the 20th century that it was realised that the common link between these familial cases was anaemia, and later still that this was of the haemolytic type. The breakthrough, in terms of an idea, came in 1938, when Darrow postulated that the baby's red cells were destroyed by an immune reaction on the part of the mother, the result of immunisation by paternal factors in the fetus. Shortly afterwards Wiener discovered an entirely new blood group system, 'Rh', and it was found that it was in­ compatibility within this system that was responsible for the vast majority of cases of haemolytic disease of the newborn.


antibody antigen bile blood circulation fetus hand immunization immunoglobulin management newborn nomenclature pathogenesis treatment women

Authors and affiliations

  • Cyril A. Clarke
    • 1
  1. 1.Department of GeneticsUniversity of LiverpoolUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1975
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6140-4
  • Online ISBN 978-94-011-6138-1
  • Buy this book on publisher's site