Women’s Health and Menopause

Risk Reduction Strategies

  • R. Paoletti
  • P. G. Crosignani
  • P. Kenemans
  • G. Samsioe
  • M. R. Soma
  • A. S. Jackson

Part of the Medical Science Symposia Series book series (MSSS, volume 11)

Table of contents

  1. Front Matter
    Pages i-xxix
  2. Menopause as a Medical and Social Issue

  3. Ovarian Senescence

    1. C. H. Matthews
      Pages 25-27
    2. Martin H. Birkhäuser
      Pages 29-38
  4. Connective Tissue and Bone

    1. Mark Brincat, Ray Galea
      Pages 45-53
    2. M. Meschia, F. Bruschi, F. Amicarelli, P. Pifarotti, M. Rossi, P. G. Crosignani
      Pages 55-59
    3. Marco Gambacciani, Massimo Ciaponi, Barbara Cappagli, Laura Piaggesi, Caterina Benussi, Stefania Picchetti et al.
      Pages 61-67
  5. Osteoporosis

  6. Cardiovascular Risk

    1. Gerd Assmann, Paul Cullen, Helmut Schulte
      Pages 91-98
    2. P. G. Crosignani, C. Boschetti, M. Cortellaro, M. Meschia
      Pages 99-103
    3. Peter Collins
      Pages 105-110
    4. G. M. C. Rosano, F. Leonardo, G. Grutter, S. L. Chierchia
      Pages 111-117
  7. Vascular Biology

    1. Fiorenza Bruschi, Michele Meschia, Fabio Amicarelli, Monica Rossi, Paola Pifarotti, PierGiorgio Crosignani
      Pages 129-133
    2. Sybille Bergmann, Cornelia Mix, Gabriele Siegert, Catleen Uhlig, Peter Richter, Werner Jaross
      Pages 135-139
    3. Mauro Penotti, Laura Sironi, Elisabetta Castiglioni, Luigi Miglierina, Stefano De Marinis, Massimiliano Farina et al.
      Pages 141-144
    4. Angelo Cagnacci, Serenella Arangino, Marco Angiolucci, Stefania Malmusi, Annibale Volpe, Gian Benedetto Melis
      Pages 145-148
  8. Cognitive Processes and Dementia in Elderly Women

    1. Luigi Amaducci, Antonio Di Carlo, Marzia Baldereschi for the Consiglio Nazionale delle Ricerche, Progetto Finalizzato Invecchiamento (Italian National Research Council Targeted Project on Aging)
      Pages 149-162
    2. Orazio Zanetti, Angelo Bianchetti, Stefano Govoni, Marco Trabucchi
      Pages 163-168
    3. Andrea R. Genazzani, Massimo Stomati, Silvia Rubino, Chiara Bersi, Rosita Gallo, Cristina Salvestroni et al.
      Pages 169-176
  9. Central Nervous System

    1. J. Galen Buckwalter, Victor W. Henderson
      Pages 185-190
    2. Paola Ianna, Marco Racchi, Elena Cattaneo, Maurizio Soma, Roberta Baetta, M. Trabucchi et al.
      Pages 191-198
    3. Diego De Leo, Gaia Meneghel
      Pages 199-208
    4. Martine Garnier, Paola Agrati, Cesare Patrone, Sabrina Santagati, Elisabetta Vegeto, Adriana Maggi
      Pages 209-215
  10. Neoplasia

    1. Hermann P. G. Schneider, Christian Jackisch
      Pages 223-232
    2. P. Kenemans, F. Scheele
      Pages 233-240
  11. HRT and the Endometrium

    1. Marius J. van der Mooren, Pierre N. M. Demacker, Antonius G. J. M. Hanselaar, Charles P. T. Schijf, Rune Rolland
      Pages 247-251
  12. HRT: Addressing the Needs of Women and Physicians

    1. Domenico de Aloysio, Paola Altieri, Paola Penacchioni
      Pages 253-256
    2. Alessandra Graziottin
      Pages 263-273
  13. The Overall Benefit and Safety Profile of CEE+MPA in a Continuous Sequential or Combined Regimen

    1. G. M. C. Rosano, F. Leonardo, G. Grutter, I. Sheiban, S. L. Chierchia
      Pages 295-302
    2. P. Sismondi, N. Biglia, M. Giai, R. Ponzone, C. Campagnoli
      Pages 303-313
  14. New Drugs and Alternative Treatment

    1. Michael Morton, Claudia Harding, Anthony Howell, Keith Griffiths, Nigel Bundred
      Pages 321-325
  15. Back Matter
    Pages 339-341

About this book


Despite its universality in human female aging, the menopause and its biology are not completely understood. New biologic mechanisms by which sex hormones may be detrimental or confer protection are continually being discovered.
We are now starting to understand that the role of the estrogen receptor is not identical in all tissues. Important nongenomic effects for sex hormones have also been described. Hormone replacement therapy (HRT) has produced effects on health risks: some are reduced, some are increased, and the rest remain uncertain. HRT is being used by an increasing number of women to alleviate climacteric symptoms in the perimenopausal period and to prevent osteoporosis and cardiovascular disease later. Positive effects on Alzheimer's disease and dementia on the one hand, and an increase in venous thrombosis on the other, are currently being reported by several groups. Both the preventive benefits and the risk of breast cancer seem to be linked to long-term and current use. HRT requires further testing through specific clinical trials, currently underway in the United States, before confident recommendations may be made about the full range of benefits and risks.


Endometrium biology cancer health hormones menopause receptor sex

Editors and affiliations

  • R. Paoletti
    • 1
  • P. G. Crosignani
    • 2
  • P. Kenemans
    • 3
  • G. Samsioe
    • 4
  • M. R. Soma
    • 5
  • A. S. Jackson
    • 6
  1. 1.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  2. 2.Department of Obstetrics and GynecologyUniversity of MilanMilanItaly
  3. 3.Department of Obstetrics and GynaecologyUniversity Hospital Vrije UniversiteitAmsterdamThe Netherlands
  4. 4.Department of Obstetrics and GynecologyLund University HospitalLundSweden
  5. 5.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  6. 6.Giovanni Lorenzini Medical FoundationHoustonUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers and Fondazione Giovanni Lorenzini 1997
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6343-2
  • Online ISBN 978-94-011-5560-1
  • Series Print ISSN 0928-9550
  • Buy this book on publisher's site