Manual of Biological Markers of Disease

  • W. J. Van Venrooij
  • R. N. Maini

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

    1. Front Matter
      Pages xiii-xiv
    2. R. Verheijen, M. Salden, W. J. Van Venrooij
      Pages 45-69
    3. E. M. Tan, C. L. Peebles
      Pages 95-107
    4. G. Zieve, M. Fury, E. J. R. Jansen
      Pages 109-121
    5. R. Smeenk
      Pages 123-134
    6. A. Wiik, N. Rasmussen, J. Wieslander
      Pages 135-148
    7. T. E. W. Feltkamp
      Pages 157-167
  3. Introduction

    1. Front Matter
      Pages 169-170
    2. Rizgar A. Mageed
      Pages 171-236
    3. Ruud J. T. Smeenk
      Pages 237-382
    4. Jacqueline M. T. Klein Gunnewiek, Walther J. Van Venrooij
      Pages 383-401
    5. Edward K. L. Chan, Jill P. Buyon
      Pages 402-431
    6. W. J. Van Venrooij, R. N. Maini
      Pages 431-491
    7. Jörgen Wieslander, Allan Wiik
      Pages 511-527
    8. Patrick S. C. Leung, Ian Mackay, M. Eric Gershwin
      Pages 530-559

About this book


Section A: Methods of Autoantibody Detection
This Section provides well structured protocols for autoantibody detection. Step-by-step procedures are accompanied by explanatory notes and comments, clear diagrams, line illustrations and excellent photo illustrations. Extensive literature references lead the way to further background information. The methods presented were validated by more than 40 leading laboratories active in sera analysis, which indicates that these methods have been found to be practically useful and lead to consistent inter-laboratory results: consensus in autoantibody detection.
Section B: Autoantigens
This Section contains the first compilation of full, detailed information on autoantigens related to important autoimmune diseases. The chapters are all structured according to an easy-reference fixed template structure: specific detection methods, cellular localization, biochemical characteristics, function, cDNA and derived amino acid sequence, gene structure, B- and T-cell epitopes and lists of published monoclonal antibodies. The text is greatly enhanced by many beautiful schematic figures and photo illustrations. As in Section A, extensive literature references are provided. The information for this section was brought together by leading experts in their fields.
This Manual is an ideal text and reference book for bench scientists working in the field of autoimmunity, but also for rheumatologists, general (internal medicine) physicians or clinical immunologists caring for patients with autoimmune disorders.


Antigen Laboratory autoimmune disease autoimmunity diseases internal medicine

Editors and affiliations

  • W. J. Van Venrooij
    • 1
  • R. N. Maini
    • 2
  1. 1.University of NijmegenThe Netherlands
  2. 2.The Mathilda and Terence Kennedy Institute of RheumatologyLondonUK

Bibliographic information