The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity

  • Jan G. J. van de Winkel
  • P. Mark Hogarth

Part of the Immunology and Medicine Series book series (IMME, volume 26)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction to the field

    1. W. H. Fridman
      Pages 1-7
  3. Physiological Role of Fc Receptors

    1. Front Matter
      Pages 9-9
    2. General aspects of FcR

      1. A. Gavin, M. Hulett, P. M. Hogarth
        Pages 11-35
      2. R. G. Lynch
        Pages 49-50
    3. FcR and Ig-transport/catabolism

    4. FcR and cell activation

      1. O. H. Choi, P. G. Holbrook
        Pages 83-93
      2. S. E. Mckenzie, Z. K. Indik, A. D. Schreiber
        Pages 95-107
      3. H. C. Morton, M. van Egmond, J. G. J. van de Winkel
        Pages 109-117
      4. A. Greinacher
        Pages 119-134
      5. H. R. Koene, A. E. G. Kr. Von Dem Borne, D. Roos, M. de Haas
        Pages 135-140
      6. H. Metzger
        Pages 151-154
    5. FcR and immunoregulation

      1. M. Sandor, R. G. Lynch
        Pages 169-183
      2. P. M. Guyre, J. K. O’Shea
        Pages 185-194
      3. D. H. Conrad
        Pages 195-206
  4. Clinical Aspects of Fc Receptors

    1. Front Matter
      Pages 213-213
    2. R. Repp, J. G. J. van de Winkel
      Pages 233-248
    3. J. E. Salmon, R. P. Kimberly
      Pages 267-278
    4. C. Sautès, J. Galon, C. Bouchard, A. Astier, J.-L. Teillaud, W. H. Fridman
      Pages 279-290
    5. C. A. Guyre, P. K. Wallace, M. W. Fanger
      Pages 291-305
    6. P. M. Hogarth, J. G. J. van de Winkel
      Pages 311-313
  5. Back Matter
    Pages 315-323

About this book


Antibodies are crucial to the fine specificity of the immune system. An effective functioning of these molecules requires interaction with immune cells. Receptors for antibodies, Fc receptors, provide this critical link between the humoral and cellular branches of the immune system. This book presents a comprehensive overview of the different Fc receptors currently recognized. The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed. The clinical importance of FcR is developed in the second part of the book. The well-recognized roles of FcR in allergy, inflammation, infectious diseases, autoimmune disorders, and immunotherapeutic importance are reviewed. The information in this book is easily accessible and should be helpful for researchers and clinical specialists as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research.


Antigen autoimmunity infectious infectious disease infectious diseases physiology

Editors and affiliations

  • Jan G. J. van de Winkel
    • 1
  • P. Mark Hogarth
    • 2
  1. 1.Utrecht UniversityUtrechtThe Netherlands
  2. 2.Austin Research InstituteMelbourneAustralia

Bibliographic information