Helicobacter pylori

Basic Mechanisms to Clinical Cure 1998

  • Richard H. Hunt
  • Guido N. J. Tytgat

Table of contents

  1. Front Matter
    Pages i-xx
  2. Helicobacter pylori - the organism

    1. Front Matter
      Pages 1-1
    2. A. Lee, B. Robertson
      Pages 3-12
    3. A. Covacci, S. Censini, C. Lange, M. Marchetti, S. Guidotti, M. Stein et al.
      Pages 13-18
    4. J. C. Atherton
      Pages 19-26
    5. B. J. Appelmelk, S. Straver, T. Verboom, E. J. Kuipers, D. Claeys, G. Faller et al.
      Pages 33-42
  3. Helicobacter pylori — transmission

    1. Front Matter
      Pages 49-49
    2. F. Mégraud, N. Broutet
      Pages 51-57
    3. D. R. Cave, P. Grübel, L. Huang
      Pages 68-74
  4. Helicobacter pylori — inflammation

    1. Front Matter
      Pages 75-75
    2. L. S. Tompkins, E. Segal, S. Falkow
      Pages 77-83
    3. M. Chmiela, B. Paziak-Domanska, S. Hirmo, W. Rudnicka, M. Utt, T. Wadström
      Pages 90-100
    4. J. G. Nedrud, M. Mohammadi, T. Blanchard, R. Redline, S. J. Czinn
      Pages 101-109
    5. S. F. Moss
      Pages 110-122
    6. P. B. Ernst, V. E. Reyes, X. -J. Fan, S. E. Crowe
      Pages 123-130
  5. Helicobacter pylori - functional secretory and motor disturbances

    1. Front Matter
      Pages 131-131
    2. D. Scott, D. Weeks, M. Rektorschek, G. Sachs, K. Melchers
      Pages 133-147
    3. L. Olbe, A. Hamlet, L. Fändriks
      Pages 148-157
    4. D. R. Cave, N. Masubuchi, P. J. Goddard
      Pages 158-168
    5. J. Calam, P. Bliss, S. Murray, G. Taylor
      Pages 169-175
    6. I. M. Modlin, M. Kidd, K. Miu, L. H. Tang
      Pages 176-187
    7. K. E. Barrett, C. P. Myers, D. Hogan, V. Pratha, J. I. Isenberg
      Pages 188-194
  6. Helicobacter pylori - pathological aspects

  7. Clinical aspects of Helicobacter pylori infection

  8. Helicobacter pylori-associated gastric cancer and lymphoma

  9. Helicobacter pylori — treatment issues

    1. Front Matter
      Pages 381-381

About this book


The explosion of new information on Helicobacter pylori-related disease, both in the basic sciences and in clinical medicine, has continued to progress at an unprecedented pace. In many instances H. pylori infection, both in man and in the laboratory animal, has become a model to investigate fundamental biological issues such as micro-organism-host interactions, intracellular signalling, development of mucosal atrophy, mechanism of microbial resistance, disease modifying factors etc. In view of this bewildering flood of new information, the time was considered right to organize yet another update on H. pylori in the successful series 'Basic mechanisms to clinical cure' to define the 'state-of-affairs' in H. pylori research at this time. Our main objective was to integrate this new information in a series of top-quality presentations and discussions between investigators and clinicians, addressing all aspects of H. pylori research, and to review the current position and future research direc­ tions. The format included state-of-the-art presentations by world experts heavily involved in H. pylori research, followed by in-depth discussion on intriguing or controversial issues. The topics discussed were grouped according to the leading theme: characteristics of the organism, mode of transmission, mechanisms of H. pylori-induced inflammation, causation of disturbances of gastric secretory and motor function, aspects of clinical presentation and management, problems related to H. pylori-associated gastric adenocarcinoma and MALT-lymphoma, novel aspects of antimicrobial therapy, and vaccination. The meeting concluded with a synoptic agenda of suggested future studies for the microbiologist, the histopathologist and the clinician.


antimicrobial antimicrobial therapy cancer carcinoma gastric cancer helicobacter pylori infection lymphoma vaccination

Editors and affiliations

  • Richard H. Hunt
    • 1
  • Guido N. J. Tytgat
    • 2
  1. 1.Division of GastroenterologyMcMaster University Medical CentreHamiltonCanada
  2. 2.Department of Gastroenterology and HepatologyAcademic Medical CentreAmsterdamThe Netherlands

Bibliographic information