Myasthenia Gravis

Disease Mechanism and Immunointervention

  • Premkumar Christadoss

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Mechanisms of Disease

    1. Anne-Marie Salmon, Corinne Bruand, Ana Cardona, Jean-Pierre Changeux, Sonia Berrih-Aknin
      Pages 20-27
    2. Alexander Marx, Annette Wilisch, Stefanie Gutsche, Viola Hoffacker, Anja Schultz, Socrates Tzartos et al.
      Pages 28-34
    3. Stefanie Gutsche, Annette Wilisch, Viola Hoffacker, Anja Schultz, Socrates Tzartos, Wilfried Nix et al.
      Pages 42-50
    4. Viola Hoffacker, Anja Schultz, Regina Nenninger, Socrates Tzartos, Hans-Konrad Müller-Hermelink, Alexander Marx
      Pages 51-57
    5. Mathilde Aurélia Poussin, Premkumar Christadoss
      Pages 58-72
    6. Bianca M. Conti-Fine, Zeng-Yu Wang, Raghavanpillai Raju, James F. Howard Jr., Duraiswamy Navaneetham
      Pages 73-93
    7. Peter Hjelmström, Carani B. Sanjeevi
      Pages 94-104
    8. Ann Kari Lefvert, DeRen Huang, Biying Xu
      Pages 105-115
    9. Fu-Dong Shi, Bing He, Hulun Li, Darius Matusevicius, Hans Link, Hans-Gustaf Ljunggren
      Pages 116-124
    10. Zeng-Yu Wang, Peter I. Karachunski, James F. Howard Jr., Bianca M. Conti-Fine
      Pages 125-140
    11. Thierry Guyon, Abdelilah Wakkach, Sandrine Poea, Vincent Mouly, Isabelle Klingel-Schmitt, Philippe Levasseur et al.
      Pages 141-149
  3. Immunointervention

    1. F. Baggi, F. Andreetta, E. Caspani, M. Milani, O. Simonicini, R. Longhi et al.
      Pages 150-160
    2. Peter I. Karachunski, Norma S. Ostlie, David K. Okita, Bianca M. Conti-Fine
      Pages 161-172
    3. Caishu Deng, Premkumar Christadoss
      Pages 195-205
  4. Back Matter
    Pages 207-208

About this book


Autoimmune myasthenia gravis (MG) is a classical autoimmune disease, for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue, and weakness.
In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model, experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune response to the acetylcholine receptor (AChR). These advances are leading to the development of specific methods of immunointervention in EAMG. Further understanding of the intricate involvement of the major histocompatibility complex (MHC) and non-MHC genes, T cell receptors (TCR), costimulator molecules, and specific cytokines in the afferent and efferent autoimmune response of AChR should pave the way to future antigen/clone-specific therapy of MG.
This book is the outcome of the MG workshop proceedings in Mysore, India, 1998. The majority of the chapters in this book are contributed by world-renowned authors and their students. The book not only contains a timely review of specific topics, but also up-to-date findings. Immunologists and neurologists will find, in this volume, the latest in MG/EAMG cutting-edge research. Clinicians will be interested in the applications of the various immunointervention strategies into clinical trials in MG patients. Finally, students will not only be interested in reading the latest in EAMG/MG research, but will also find information to help them develop a future strategy to unravel the precise mechanism of disease.
To summarize, in this book, the readers should find up-to-date information related to immunological mechanisms involved in MG pathogenesis and various modalities for possible approaches to immunointervention to treat MG.


Antigen T cell Thymus autoimmune disease blood cell clinical trial cytokine histocompatibility muscle pathogenesis protein receptor

Editors and affiliations

  • Premkumar Christadoss
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of Texas Medical BranchGalvestonUSA

Bibliographic information

  • DOI
  • Copyright Information Narosa Publishing House, New Delhi, India 2000
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-5787-5
  • Online ISBN 978-94-011-4060-7
  • Buy this book on publisher's site