Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters

  • Martin Morad
  • Setsuro Ebashi
  • Wolfgang Trautwein
  • Yoshihisa Kurachi

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 182)

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Part One

    1. Front Matter
      Pages 1-1
    2. Channels and channel proteins

      1. H. Criss Hartzell
        Pages 3-15
      2. Samuel C. Dudley Jr., Harry A. Fozzard
        Pages 39-51
      3. Makoto Arita, Hikaru Muramatsu, Katsushige Ono, Tatsuto Kiyosue
        Pages 53-62
      4. Franz Hofmann, Martin Biel
        Pages 63-69
      5. Timothy J. Kamp, Eduardo Marban
        Pages 71-80
      6. Wolfgang Trautwein, Josef Utz
        Pages 81-91
      7. Rodolphe Fischmeister, Pierre-François Méry
        Pages 93-105
      8. David Fedida, Arthur M. Brown
        Pages 119-130
      9. W. R. Giles, R. B. Clark, A. P. Braun
        Pages 141-168
      10. Joseph R. Hume, Paul C. Levesque, Pádraig Hart, Mei Lin Collier, John D. Warth, Yvonne Geary et al.
        Pages 187-196
      11. David C. Spray, Glenn I. Fishman
        Pages 209-221
      12. Nobuhisa Hagiwara, Naoki Matsuda, Rieko Sakai, Hiroshi Kasanuki, Saichi Hosoda
        Pages 223-229
      13. Guy Vassort, Michel Pucéat, Julio Alvarez
        Pages 231-238
    3. Ion channels in cardiovascular development

      1. Jürgen Hescheler, Victor A. Maltsev, Anna M. Wobus
        Pages 241-249
      2. Nicholas Sperelakis, Zhiling Xiong, Hiroshi Masuda, Noritsugu Tohse
        Pages 251-272
    4. Pharmacology of ion channels

      1. David J. Triggle
        Pages 275-289
      2. Terence F. McDonald, Siegried Pelzer, Dieter J. Pelzer
        Pages 291-304
      3. Yoshihisa Kurachi, André Terzic, Ian Findlay
        Pages 305-312
      4. Donghee Kim
        Pages 313-322
      5. Edward Carmeliet
        Pages 323-329
    5. Ion channels and cardiac pathology

      1. Robert F. Gilmour Jr., Douglas P. Zipes
        Pages 333-342
      2. Masayasu Hiraoka, Tohru Sawanobori, Seiko Kawano, Yuji Hirano
        Pages 343-349
      3. Edward Carmeliet
        Pages 351-355
      4. James N. Weiss, Nicholas Deutsch, Joshua I. Goldhaber
        Pages 357-371
  3. Part Two

    1. Front Matter
      Pages 373-373
    2. Molecular aspects of Ca2+ release

    3. Molecular steps in cardiac relaxation

      1. David H. MacLennan, Stefan J. Becker
        Pages 411-425
      2. Kenneth D. Philipson
        Pages 435-445
      3. W. Jonathan Lederer, P. Kofuji, A. Doering, E. Niggli, P. Lipp, R. S. Kieval et al.
        Pages 447-455
      4. John H. B. Bridge
        Pages 469-480
      5. Edward G. Lakatta
        Pages 481-511
    4. Regulation of cellular CA2+ by other transporters

      1. Craig C. Freudenrich, Sarah K. Hall, Melvyn Lieberman, Elizabeth Murphy
        Pages 563-573

About this book


Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.


biology cardiovascular electrophysiology heart pathophysiology physiology research

Editors and affiliations

  • Martin Morad
    • 1
  • Setsuro Ebashi
    • 2
  • Wolfgang Trautwein
    • 3
  • Yoshihisa Kurachi
    • 4
  1. 1.Department of PharmacologyGeorgetown University Medical CenterNWUSA
  2. 2.National Institute for Physiological SciencesOkazaki 444Japan
  3. 3.Department of Physiology, II Physiological InstituteUniversity of SaarlandHomburg/SaarGermany
  4. 4.Department of Pharmacology II, Faculty of MedicineOsaka UniversitySuita, Osaka 565Japan

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 1996
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-5765-3
  • Online ISBN 978-94-011-3990-8
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site