Immunology of Renal Disease

  • C. D. Pusey

Part of the Immunology and Medicine Series book series (IMME, volume 16)

Table of contents

  1. Front Matter
    Pages i-x
  2. A. Burns, P. Li, A. Rees
    Pages 1-28
  3. K. A. Davies, M. J. Wallport
    Pages 59-80
  4. S. R. Holdsworth, P. G. Tipping
    Pages 97-122
  5. J. D. Williams, M. Davies
    Pages 123-160
  6. G. Clark, D. G. Williams
    Pages 161-181
  7. F. W. Ballardie
    Pages 183-213
  8. N. Turner, C. D. Pusey
    Pages 229-254
  9. D. R. W. Jayne, C. M. Lockwood
    Pages 255-269
  10. C. M. Meyers, C. J. Kelly
    Pages 271-288
  11. Back Matter
    Pages 289-294

About this book


Although it has been appreciated for many years that immune processes underlie most types of glomerulonephritis, it is the recent explosion in knowl­ edge of cellular and molecular immunology that has prompted another book on the subject. The understanding of the mechanisms involved in renal injury requires the integration of information from in vitro cell-culture systems, experimental models of disease, and clinical studies. This volume draws on all of these sources in an attempt to explain current concepts of nephritis. Increased emphasis is placed on autoimmune processes, as opposed to the deposition of circulating immune complexes, although it will be apparent that these may overlap in the area of "in situ" immune complex formation. Of central importance in autoimmunity is the relationship between antigen pre­ senting cells (including B cells) expressing MHC class II molecules, autoan­ tigenic peptides, T helper lymphocytes, and various effector cells. The mechanisms by which the immune system may lead to tissue injury are also becoming better understood, and consideration is given to the role of inflam­ matory cells, the complement proteins, and soluble factors such as cytokines and eicosanoids.



Editors and affiliations

  • C. D. Pusey
    • 1
  1. 1.Renal Unit, Department of Medicine, Royal Postgraduate Medical SchoolHammersmith HospitalLondonUK

Bibliographic information