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Molecular Basis of Specificity in Nucleic Acid-Drug Interactions

Proceedings of the Twenty-Third Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 14–17, 1990

  • Bernard Pullman
  • Joshua Jortner

Part of the The Jerusalem Symposia on Quantum Chemistry and Biochemistry book series (JSQC, volume 23)

Table of contents

  1. Front Matter
    Pages i-x
  2. Andrew H.-J. Wang, Yen-Chywan Liaw, Howard Robinson, Yi-Gui Gao
    Pages 1-21
  3. B. Nordén, S. Eriksson, S. K. Kim, M. Kubista, R. Lyng, B. Åkerman
    Pages 23-41
  4. S. Neidle, D. G. Brown, T. C. Jenkins, C. A. Laughton, M. R. Sanderson, J. V. Skelly
    Pages 43-57
  5. Richard H. Shafer, Mitsuru Yoshida, Debra L. Banville, Sungho Hu
    Pages 59-65
  6. Ramaswamy H. Sarma, Mukti H. Sarma, Kimiko Umemoto, Goutam Gupta, Angel E. Garcia
    Pages 75-93
  7. D. E. Wemmer, P. Fagan, J. G. Pelton
    Pages 95-101
  8. Robert Rehfuss, Jerry Goodisman, James C. Dabrowiak
    Pages 157-166
  9. Manlio Palumbo, Barbara Gatto
    Pages 207-224
  10. Johan H. van de Sande, Bernd W. Kalisch, Markus W. Germann
    Pages 261-274
  11. T. Montenay-Garestier, J. S. Sun, J. Chomilier, J. L. Mergny, M. Takasugi, U. Asseline et al.
    Pages 275-290
  12. C. Helene, J. C. Francois, C. Giovannangeli, T. Saison-Behmoaras, U. Asseline, N. T. Thuong
    Pages 291-299
  13. J. D. Hoeschele, A. J. Kraker, Y. Qu, B. Van Houten, N. Farrell
    Pages 301-321
  14. Nada Zein, Wei-Dong Ding, George A. Ellestad
    Pages 323-330
  15. W. David Wilson, Farial A. Tanious, Henryk Buczak, M. K. Venkatramanan, B. P. Das, David W. Boykin
    Pages 331-353
  16. Bruce C. Baguley, Karen M. Holdaway, Graeme J. Finlay
    Pages 355-367
  17. Robert J. Fiel, Bruce G. Jenkins, James L. Alderfer
    Pages 385-399
  18. Peter E. Nielsen, Benjamin M. G. Cons, Keith R. Fox, Vibeke Beck Sommer
    Pages 423-431
  19. Michael P. Stone, S. Gopalakrishnan, Kevin D. Raney, Veronica M. Raney, Suzanne Byrd, Thomas M. Harris
    Pages 451-480
  20. L. L. Shen, M. G. Bures, D. T. W. Chu, J. J. Plattner
    Pages 495-512
  21. Martha A. Warpehoski, Patrick McGovren, Mark A. Mitchell, Laurence H. Hurley
    Pages 531-550

About these proceedings

Introduction

One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.

Keywords

biochemistry chemistry nucleic acid

Editors and affiliations

  • Bernard Pullman
    • 1
  • Joshua Jortner
    • 2
  1. 1.Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild)ParisFrance
  2. 2.Department of ChemistryUniversity of Tel-AvivIsrael

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-3728-7
  • Copyright Information Kluwer Academic Publishers 1990
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-5657-1
  • Online ISBN 978-94-011-3728-7
  • Series Print ISSN 0924-4875
  • Buy this book on publisher's site