Coronary Blood Flow

Mechanics, Distribution, and Control

  • Jos A. E. Spaan

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 124)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Jos A. E. Spaan
    Pages 1-36
  3. Jos A. E. Spaan
    Pages 69-86
  4. Ed van Bavel, Maurice J. M. M. Giezeman, Jos A. E. Spaan
    Pages 193-218
  5. Jenny Dankelman, Isabelle Vergroesen, Jos A. E. Spaan
    Pages 219-259
  6. Isabelle Vergroesen, Yves Han, Jenny Dankelman, Jos A. E. Spaan
    Pages 261-289
  7. Jos A. E. Spaan, Peter A. Wieringa
    Pages 291-332
  8. Jos A. E. Spaan, Jan Verburg
    Pages 333-361
  9. Back Matter
    Pages 363-396

About this book


by JULIEN IE HOFFMAN One of the earliest coronary physiologists was Scaramucci who, in 1695, postu­ lated that during systole the contracting myocardium inhibited coronary blood flow. Since then, the many contributions that have been made to our knowledge of the coronary circulation can be arbitrarily divided into three phases based on advances in technical methods. The early phase of research into the coronary circulation, done with great difficulty with crude methods, may be regarded as ending in the 1940s, and it included major discoveries made by such well known investigators as Georg von Anrep, Ernest Starling, Carl Wiggers, and Louis Katz, who formulated much of our basic understanding of the field. After 1940, the field of coronary physiology entered a new phase when instruments for high fidelity registration of coronary flow and pressure became available. This era was domi­ nated by Donald Gregg who combined careful attention to the function of these instruments (some of which he helped to develop) with an extraordinary ability to discern mechanisms from apparently minor changes in coronary flow and pressure patterns. His book 'The Coronary Circulation in Health and Disease' set a new standard in the field. After 1960, techniques for measuring regional myocardial blood flow became available, and enabled a large group of eminent investigators to make major advances in understanding the physiology and pathophysiology of myocardial blood flow.


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Authors and affiliations

  • Jos A. E. Spaan
    • 1
  1. 1.Cardiovascular Research Institute Amsterdam (CRIA)AmsterdamThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 1991
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-5388-4
  • Online ISBN 978-94-011-3148-3
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site