ECAT Assay Procedures A Manual of Laboratory Techniques

European Concerted Action on Thrombosis and Disabilities of the Commission of the European Communities

  • Jørgen Jespersen
  • Rogier M. Bertina
  • F. Haverkate

Table of contents

  1. Front Matter
    Pages i-x
  2. S. G. Thompson, J. M. Thomson
    Pages 1-11
  3. D. S. Pepper, C. V. Prowse
    Pages 21-34
  4. L. Poller, J. M. Thomson
    Pages 35-40
  5. L. Poller
    Pages 41-45
  6. G. A. Marbet, F. Duckert
    Pages 47-55
  7. G. A. Marbet, F. Duckert
    Pages 57-63
  8. P. M. Mannucci, A. Tripodi
    Pages 65-70
  9. P. M. Mannucci, R. Coppola
    Pages 71-75
  10. R. M. Bertina
    Pages 85-98
  11. R. M. Bertina
    Pages 99-108
  12. A. Haeberli
    Pages 109-116
  13. J. Harenberg
    Pages 117-123
  14. P. C. Cooper, F. E. Preston
    Pages 125-129
  15. I. Juhan-Vague, M. C. Alessi
    Pages 131-137
  16. J. H. Verheijen
    Pages 139-146
  17. E. K. O. Kruithof
    Pages 147-150
  18. E. K. O. Kruithof
    Pages 151-153
  19. P. J. Gaffney
    Pages 155-163
  20. C. Kluft
    Pages 165-171
  21. E. Hattey, M. Haumer, A. Binder, B. R. Binder
    Pages 173-183
  22. A. Haeberli
    Pages 205-212
  23. Jørgen Jespersen, Rogier M. Bertina, F. Haverkate
    Pages 217-224
  24. Back Matter
    Pages 225-230

About this book


This book offers a description of current and recently developed laboratory assays in the field of haemostasis and thrombosis. It is the result of a unique cooperation between experts from more than 60 institutes in 12 European countries, brought together by the ECA T (European Concerted Action on Thrombosis and Disabilities) under the auspices of the Commission of the European Communities in Brussels, Belgium. The ECAT, which was initiated in 1981, designed and performed three prospective clinical studies to establish haemostatic factors as risk indicators of thrombosis. Included were patients with angina pectoris at risk from myocardial infarction, patients undergoing angioplasty at risk from re-stenosis, and patients receiving hip replacement at risk from deep venous thrombosis. Assay procedures were chosen, training courses for technicians held, and essential reagents were supplied from a central source. A quality control assessment scheme served to compare assay results both within and between laboratories. In the angina pectoris study, centres determined most of the assays locally; in the other two studies assays were performed centrally. The need for further quality assessment in Europe Dr J. F. Davidson in Glasgow, led to a separate activity coordinated by including coagulation inhibitors and plasminogen as risk factors for familial venous thrombosis. The Editors hope the ECA T Assay Procedures book will contribute to further harmonization ofhaemostasis assays, and ultimately to their standardization.


Laboratory Laboratory Techniques blood enzymes plasma thrombosis

Editors and affiliations

  • Jørgen Jespersen
    • 1
  • Rogier M. Bertina
    • 2
  • F. Haverkate
    • 3
  1. 1.Department of Clinical ChemistryRibe County Hospital in EsbjergEsbjergDenmark
  2. 2.Haemostasis and Thrombosis Research UnitUniversity Hospital LeidenLeidenThe Netherlands
  3. 3.Gaubius LaboratoryIVVO-TNOLeidenThe Netherlands

Bibliographic information