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Disulfiram and its Metabolite, Diethyldithiocarbamate

Pharmacology and status in the treatment of alcoholism, HIV infections, AIDS and heavy metal toxicity

  • Peter K. Gessner
  • Teresa Gessner

Table of contents

  1. Front Matter
    Pages i-xix
  2. Peter K. Gessner, Teresa Gessner
    Pages 1-6
  3. Peter K. Gessner, Teresa Gessner
    Pages 7-12
  4. Peter K. Gessner, Teresa Gessner
    Pages 21-28
  5. Peter K. Gessner, Teresa Gessner
    Pages 29-42
  6. Peter K. Gessner, Teresa Gessner
    Pages 95-135
  7. Peter K. Gessner, Teresa Gessner
    Pages 137-166
  8. Peter K. Gessner, Teresa Gessner
    Pages 167-203
  9. Peter K. Gessner, Teresa Gessner
    Pages 205-246
  10. Peter K. Gessner, Teresa Gessner
    Pages 247-277
  11. Peter K. Gessner, Teresa Gessner
    Pages 279-293
  12. Peter K. Gessner, Teresa Gessner
    Pages 295-312
  13. Peter K. Gessner, Teresa Gessner
    Pages 313-334
  14. Peter K. Gessner, Teresa Gessner
    Pages 335-345
  15. Back Matter
    Pages 347-452

About this book

Introduction

This book is aimed at those in the biomedical community that are interested in the therapeutic applications, pharmacology, biochemistry, toxicology and pharmacokinetics of the title compounds. Recent findings regarding the ability of diethyldithiocarbamate (ditiocarb, Imuthiol®) to delay the progression of HN infections and AIDS, the discovery of its potential as a rescue agent in cancer chemotherapy, and the identification of disulfiram (Antabuse®) regimens that allow alcoholics to achieve abstinence of many months' duration have made writing this book an exciting experience. At the same time the fact that the two drugs differ substantially in their pharmacological effects in spite of their easy interconvertibility has rendered the writing intellec­ tually challenging. Diethyldithiocarbamate, an agent seemingly less toxic than aspirin, rivals it in the multiplicity and diversity of its pharmacological proper­ ties. Notable among these are the manyfold potent immunostimulant effects, and though most of these involve effects on T -cells, the mechanism of diethyldithiocarbamate's action remains far from clear. The drug is also a potent chelator of heavy metals and this has led to a number of clinical applications. As might be expected, it inhibits several important enzymes. Further, it is one of the most effective radioprotective agents; it also protects organisms against a variety of toxic agents.

Keywords

Drogen alcoholism cancer chemotherapy enzyme enzymes ethanol metabolism pharmacology research toxicology

Authors and affiliations

  • Peter K. Gessner
    • 1
  • Teresa Gessner
    • 2
  1. 1.School of Medicine and Biomedical SciencesState University of New York at BuffaloBuffaloUSA
  2. 2.Roswell Park Graduate Division, Roswell Park Cancer InstituteState University of New York at BuffaloBuffaloUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-2328-0
  • Copyright Information Peter K. Gessner and Teresa Gessner 1992
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-5028-9
  • Online ISBN 978-94-011-2328-0
  • Buy this book on publisher's site