Applications of Supercritical Fluids in Industrial Analysis

  • John R. Dean

Table of contents

  1. Front Matter
    Pages i-xiv
  2. S. M. Hitchen, J. R. Dean
    Pages 1-11
  3. J. R. Dean, M. Kane
    Pages 46-73
  4. I. D. Wilson, P. Davis, R. J. Ruane
    Pages 74-103
  5. D. E. Knowles, T. K. Hoge
    Pages 104-129
  6. V. Janda, K. Bartle, A. A. Clifford
    Pages 159-187
  7. Back Matter
    Pages 219-224

About this book


The continued search for rapid, efficient and cost-effective means of analytical measurement has introduced supercritical fluids into the field of analytical chemistry. Two areas are common: supercritical fluid chroma­ tography and supercritical fluid extraction. Both seek to exploit the unique properties of a gas at temperatures and pressures above the critical point. The most common supercritical fluid is carbon dioxide, employed because of its low critical temperature (31 °C), inertness, purity, non-toxicity and cheapness. Alternative supercritical fluids are also used and often in conjunction with modifiers. The combined gas-like mass transfer and liquid-like solvating characteristics have been used for improved chroma­ tographic separation and faster sample preparation. Supercritical fluid chromatography (SFC) is complementary to gas chro­ matography ( GC) and high performance liquid chromatography (HPLC), providing higher efficiency than HPLC, together with the ability to analyse thermally labile and high molecular weight analytes. Both packed and open tubular columns can be employed, providing the capability to analyse a wide range of sample types. In addition, flame ionization detection can be used, thus providing 'universal' detection.


Atom Chromat Lipid chromatography extraction pharmaceutical chemistry polymer supercritical fluid

Editors and affiliations

  • John R. Dean
    • 1
  1. 1.Department of Chemical and Life SciencesUniversity of Northumbria at NewcastleUK

Bibliographic information