Nicotine and Related Alkaloids

Absorption, distribution, metabolism and excretion

  • J. W. Gorrod
  • J. Wahren

Table of contents

  1. Front Matter
    Pages i-xvii
  2. L. P. Bush, F. F. Fannin, R. L. Chelvarajan, H. R. Burton
    Pages 1-30
  3. H. Nakayama, T. Kita, T. Nakashima, S. Imaoka, Y. Funae
    Pages 45-59
  4. G. B. Neurath
    Pages 61-80
  5. X. Liu, P. Jacob III, N. Castagnoli Jr
    Pages 129-145
  6. M. Curvall, E. Kazemi Vala
    Pages 147-179
  7. J. Gabrielsson, M. Gumbleton
    Pages 181-195
  8. P. Jacob III, N. L. Benowitz
    Pages 197-218
  9. S. Cholerton, N. W. McCracken, J. R. Idle
    Pages 219-254
  10. S. L. Schwartz, M. R. Gastonguay, D. E. Robinson, N. J. Balter
    Pages 255-274
  11. J. Wahren, J. Gabrielsson, M. Curvall, E. Kazemi Vala
    Pages 275-283
  12. Back Matter
    Pages 285-299

About this book


Nicotine is an alkaloid which is present, together with a number of minor alkaloids, in tobacco and a wide variety of other plants. The introduction of tobacco as a therapeutic agent against diverse pathologi­ cal and physiological conditions resulted in the widespread exposure of people to nicotine, and the subsequent recognition of the pleasurable effects of tobacco consumption. Tobacco may be used for pleasure by smoking it in pipes, cigars or cigarettes or by taking it in unsmoked form as oral and nasal tobacco snuff. Nonsmokers are exposed to nico­ tine through plant material and side-stream tobacco smoke. This means that in humans nicotine is always utilized in the presence of a very large variety of natural compounds or their pyrolysis products, depend­ ing on the route of administration. These compounds may modify the absorption, distribution, metabolism and excretion of nicotine and hence alter the duration of its pharmacological action. In recent years the use of nicotine in chewing gum and cutaneous patches has been developed as an aid to smoking cessation. The toxic properties of nicotine make it useful as an insecticide, which has led to its use in agriculture and horticulture. It has also recently been recog­ nized that tobacco consumption may be beneficial in the prevention of Parkinson's disease or in alleviating inflammatory bowel syndrome. The above observations have continued to stimulate research into the mode of action of this relatively simple molecule.


Oxidation absorption alkaloids enzyme enzymes kinetics metabolism methylation pharmacokinetics research

Editors and affiliations

  • J. W. Gorrod
    • 1
  • J. Wahren
    • 2
  1. 1.Chelsea Department of PharmacyKing’s CollegeLondonUK
  2. 2.Department of Clinical PhysiologyKarolinska InstituteStockholmSweden

Bibliographic information