Neurohumoral Regulation of Coronary Flow

Role of the Endothelium

  • W. H. van Gilst
  • K. I. Lie

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 150)

Table of contents

  1. Front Matter
    Pages i-ix
  2. H. Buikema, W. H. van Gilst
    Pages 1-18
  3. P. K. Blanksma
    Pages 19-26
  4. P. den Heyer, R. B. van Dijk, H. Hillege, M. L. Pentinga, K. I. Lie
    Pages 57-71
  5. J. G. Meeder, P. K. Blanksma, R. L. Anthonio, A. T. M. Willemsen, J. Pruim
    Pages 73-88
  6. J. Brouwer, W. H. van Gilst, K. I. Lie
    Pages 89-101
  7. S. A. J. van den Broek, P. A. de Graeff, W. H. van Gilst
    Pages 121-135
  8. Back Matter
    Pages 147-150

About this book


During the last decade we have witnessed a rapid expansion of our knowledge of the role of the endothelium in the control of vascular tone and hemostasis. In paricular, developments in molecular biology have enabled us to understand its physiology in greater detail. Furthermore, it is now clear that dysfunction of the endothelium contributes to various cardiovascular diseases. This is especially true for the coronary vascular bed. Development of atherosclerosis, disturbed vasomotor tone in stable ischemic syndromes, and the interaction of thrombocytes with the endothelium in acute ischemic syndrome are all consequences of endothelium dysfunction. Also, secondary changes in endothelial function have been described, for instance in chronic heart failure. This monograph reviews the present knowledge of the role of the endothelium in the control of coronary flow. The authors lead the reader through this topic starting at the basic physiology of endothelial function and the principles of coronary flow regulation. Next, the use of modern clinical techniques to evaluate endothelial function such as positron emission tomography and angioscopy are discussed. Subsequently, several pathophysiological processes and the role of endothelium are addressed. Finally, the interaction of various presently used cardiovascular drugs with the endothelium is indicated. It is the combination of basic sciences with clinical observations in this book which may be appreciated by a large number of scientists and physicians active in the field of cardiovascular disease. It is also this combination of different disciplines which will determine future developments and new avenues in pharmacotherapy involving the endothelium.


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Editors and affiliations

  • W. H. van Gilst
    • 1
  • K. I. Lie
    • 2
  1. 1.Department of Clinical PharmacologyUniversity Hospital GroningenGroningenThe Netherlands
  2. 2.Department of Cardiology Thorax-CenterUniversity Hospital GroningenGroningenThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 1993
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-4839-2
  • Online ISBN 978-94-011-1900-9
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site