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Is Crohn’s Disease a Mycobacterial Disease?

  • Chris J. J. Mulder
  • Guido N. J. Tytgat

Part of the Developments in Gastroenterology book series (DIGA, volume 14)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Jan Haagsma, Chris J. J. Mulder, Anthony Eger, Guido N. J. Tytgat
    Pages 16-21
  3. Georg Kreuzpaintner, Richard Kölble, Axel Wallner, Rudolf Hesterberg, Marie Francoise Thorel, Lutz Thomas et al.
    Pages 22-34
  4. Pranab K. Das, Ada W. Slob, Arnold Stronkhorst, Sander J. H. van Deventer, Guido N. J. Tytgat
    Pages 35-45
  5. J. D. Sanderson, M. T. Moss, M. L. V. Tizard, J. Hermon-Taylor
    Pages 46-48
  6. Arnold Stronkhorst, Guido N. J. Tytgat, Sander J. H. van Deventer
    Pages 54-63
  7. Fouad A. K. El-Zaatari, David Y. Graham
    Pages 70-75
  8. Back Matter
    Pages 77-77

About this book

Introduction

IS CROHN'S DISEASE A MYCOBACTERIAL DISEASE'! The fact that the differential diagnosis of inflammatory bowel disease includes intestinal infections has been a source of much interest and clinical concern for many years. Since the recognition of ulcerative colitis and Crohn's disease as clinical entities, numerous attempts have been made to identify a specific organism resulting in the clinical and pathologic picture of Inflammatory Bowel Disease. The first suggestion about a connection between Johne's disease, a chronic mycobacterial enteritis in cattle, and Crohn' s disease occurred in 1913, when Dalziel described enteritis in humans which, although resembling intestinal tuberculosis, he believed to be a new disorder. Since the work of Crohn in the thirties a few investigators attempted to look for mycobacteria in Crohn's disease. Until now the work of Van Patter, Burnham and others did not receive widespread recognition. In 1984 the isolation of M. paratuberculosis was reported by Chiodini et al. This report initiated the current interest and controversy about a mycobacterial etiology in Crohn's disease. The hypothesis "Crohn's disease is Johne's disease" did not receive widespread recognition, but has lead to the first muIticentered efforts to determine whether or not mycobacteria are associated with Crohn's disease.

Keywords

antigen diagnosis immunotherapy infection tuberculosis

Editors and affiliations

  • Chris J. J. Mulder
    • 1
  • Guido N. J. Tytgat
    • 2
  1. 1.Department of Hepato-gastroenterologyRijnstate HospitalArnhemThe Netherlands
  2. 2.Department of Hepato-gastroenterologyAcademic Medical CentreAmsterdamThe Netherlands

Bibliographic information