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Test Procedures for the Blood Compatibility of Biomaterials

  • S. Dawids

Table of contents

  1. Front Matter
    Pages i-xii
  2. General Introduction

  3. Test Methods for the Detection of Mechanical Properties

    1. W. Lemm, S. Dawids
      Pages 35-43
    2. W. Lemm
      Pages 49-53
    3. W. Lemm
      Pages 55-57
    4. W. Lemm
      Pages 63-66
    5. W. Lemm
      Pages 71-73
  4. Test Methods for the Detection of Biodegradation

    1. W. Lemm
      Pages 79-87
    2. W. Lemm
      Pages 105-113
  5. Test Methods for Surface Analysis

  6. Test Methods for the Detection of Protein Adsorption on Polymers

  7. Test Methods for the Activation of Haemostasis and Other Activation Systems

    1. J.-P. Cazenave
      Pages 331-331
    2. W. Lemm
      Pages 333-357
    3. J.-P. Cazenave, J. N. Mulvihill, A. Sutter-Bay, C. Gachet, F. Toti, A. Beretz
      Pages 359-375
    4. J. N. Mulvihill, A. Poot, T. Beugeling, A. Bantjes, W. B. van Aken, J.-P. Cazenave
      Pages 377-393
    5. C. Klein-Soyer, J.-P. Mazzucotelli, A. Beretz, G. Archipoff, C. Brisson, J.-P. Cazenave
      Pages 409-423
    6. L. Grunebaum, D. Gobaille, M. Grunert, M.-L. Wiesel, J.-M. Freyssinet
      Pages 425-430
    7. J.-P. Cazenave, J. N. Mulvihill, A. Sutter-Bay, C. Gachet, F. Toti, A. Beretz
      Pages 431-439
    8. J.-M. Freyssinet, C. Wagner, L. Grunebaum, M.-L. Wiesel
      Pages 441-447
    9. M.-L. Wiesel, J. Dambach, L. Grunebaum, J.-M. Freyssinet
      Pages 449-458
  8. Test Methods for the Detection of Thrombosis, Fibrinolysis and Emboli Formation

    1. R. Eloy, J.-P. Cazenave
      Pages 459-460
    2. M.-C. Rissoan, R. Eloy, J. Baguet
      Pages 461-480
    3. E. Chignier, R. Eloy
      Pages 481-493
    4. E. Chignier, R. Eloy
      Pages 495-507
    5. E. Chignier, J. Guidollet, R. Eloy
      Pages 509-533
  9. Test Methods for the Detection of Toxicity

    1. S. Dawids, R. Eloy
      Pages 535-536
    2. M. F. Sigot-Luizard, R. Warocquier-Clerout
      Pages 545-567
    3. M. F. Sigot-Luizard, R. Warocquier-Clerout
      Pages 569-594
  10. GLP-GMP Rules for Testing of Polymers

    1. S. Dawids
      Pages 595-598

About this book

Introduction

This book represents the first European effort to provide a collection of test descriptions used in evaluation of the compatibility of biomaterials in contact with tissues and blood. The urge to compile this book arose from the fact that it is the properties of the material which ultimatively seem to determine the functional outcome of a medical device, almost regardless of how ingenious the construction of the very device is. The longer the exposure is, the more important these basic properties become. Unfortunately only a small part of the interactive phenomena is fully elucidated and understood. This challenge reflects itself in an effort to cover numerous aspects of testing, beginning with fundamental analysis of the material, continuing with the mechanical properties, the resistance to degradation and the analysis of surface and chemical properties including adsorption patterns of proteins ending with test on cell cultures, ex vivo and in vivo. A number of the tests which are generally accepted as being important are already described as official requirements (primarily Pharmacopeas). These official requirements are not included in order to limit the size of the book. It is the aim of this book to present the tests like a recipe in a uniform way to ease the reader in finding his/her way through the material and to present it as a kind of "cook-book" in an order to provide an easy access to copy the procedures. This has unfortunately not been possible in all circumstances.

Keywords

biomaterial polymer surface

Editors and affiliations

  • S. Dawids
    • 1
  1. 1.Konstruktionsteknik/DTH, Instituttet for KonstruktionsteknikDanmarks Tekniske HøjskoleLyngbyDenmark

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-1640-4
  • Copyright Information Springer Science+Business Media Dordrecht 1993
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-4716-6
  • Online ISBN 978-94-011-1640-4
  • Buy this book on publisher's site