PET Studies on Amino Acid Metabolism and Protein Synthesis

Proceedings of a Workshop held in Lyon, France within the framework of the European Community Medical and Public Health Research

  • B. M. Mazoyer
  • W. D. Heiss
  • D. Comar

Part of the Developments in Nuclear Medicine book series (DNUM, volume 23)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Biochemistry and animal studies

    1. A. Lajtha, D. Dunlop, M. Banay-Schwartz
      Pages 1-17
    2. P. Bobillier, E. Grange, A. Gharib, M. Leclerc, N. Sarda, P. Lepetit
      Pages 41-52
    3. A. M. Planas, C. Prenant, B. M. Mazoyer, S. Chadan, D. Comar, L. Digiamberardino
      Pages 53-68
    4. Back Matter
      Pages 69-74
  3. PET Radiochemistry

  4. Amino acid uptake modeling

    1. K. Wienhard, K. Herholz, H. H. Coenen, J. Rudolf, P. Kling, G. Stöcklin et al.
      Pages 133-147
    2. Anne M. J. Paans, Philip H. Elsinga, Willem Vaalburg
      Pages 161-174
    3. G.-J. Meyer, J. Van Den Hoff, W. Burchert, H. Hundeshagen
      Pages 183-196
    4. Back Matter
      Pages 201-201
  5. Clinical applications

    1. S. Leskinen-Kallio
      Pages 223-225
    2. G.-J. Meyer, W. Burchert, K.-F. Gratz, H. Hundeshagen
      Pages 227-236
    3. B. Sadzot, B. Kaschten, G. Delfiore, J. M. Peters, A. Stevenaert, G. Franck et al.
      Pages 243-254
    4. A. M. Planas, B. Kaschten, B. Sadzot, A. Stevenaert, L. Digiamberardino, D. Comar
      Pages 265-268
    5. Back Matter
      Pages 267-268
  6. Back Matter
    Pages 269-270

About this book


Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given.
This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration', held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts:
  • biochemistry and animal studies;
  • amino acids labelling with positron emittors, quality control and metabolites measurement;
  • kinetic modelling of amino acids transport, metabolism, and protein incorporation;
  • clinical use of amino acids.
This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists.


Amino acid Tumor biochemistry diagnosis metabolism proteins tissue

Editors and affiliations

  • B. M. Mazoyer
    • 1
  • W. D. Heiss
    • 2
  • D. Comar
    • 3
  1. 1.Groupe d’Imagerie Neuro-fonctionelleService Hospitalier Frédéric Joliot, CEA-DRIPP Orsay, et Hôpital R. DebréParisFrance
  2. 2.Max-Planck-Institute for Neurological ResearchCologneGermany
  3. 3.E.E.C. Concerted Action on PET Investigations of Cellular Regeneration and DegenerationService Hospitalier Frédéric Joliot, Hôpital d’OrsayOrsayFrance

Bibliographic information