Immunology of Liver Disease

  • H. C. Thomas
  • J. Waters

Part of the Immunology and Medicine Series book series (IMME, volume 21)

Table of contents

  1. Front Matter
    Pages i-x
  2. B. A. Askonas
    Pages 1-9
  3. E. A. Brown, J. Ticehurst, S. M. Lemon
    Pages 11-37
  4. M. U. Mondelli, F. Negro
    Pages 39-55
  5. J. Monjardino
    Pages 57-67
  6. M. Peakman, D. Vergani, A. L. W. F. Eddleston
    Pages 85-109
  7. M. P. Manns, K. -H. Meyer Zum Büschenfelde
    Pages 111-120
  8. D. E. J. Jones, W. L. Gregory, M. F. Bassendine
    Pages 121-143
  9. R. D. Goldin, N. C. A. Hunt
    Pages 157-172
  10. J. G. Kenna
    Pages 173-200
  11. Back Matter
    Pages 201-209

About this book


The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. This book aims to present the current understanding of the involvement of the immune response in liver disease. The first chapters examine the role of the immune response in viral infections of the liver. These viruses cause hepatitis of varying severity and it is thought that many of the mechanisms responsible for liver cell injury are immunologically mediated. In addition three of these viruses, hepatitic B, C, and D, are associated with persistent infection and chronic liver disease. The role of the immune response in viral persistence is discussed. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue. There has been much recent research on cellular immune responses in these diseases but knowledge of the immunological processes which lead to the breakdown of tolerance and the mechanisms of tissue damage are limited. Other research has concentrated on the identification of the antigens which are the targets of this immune response. Linkage disequilibrium between MHC alleles and autoimmune diseases has suggested a role for immunogenetic factors.


Antigen autoimmune disease autoimmunity diseases hepatitis immunobiology immunology immunotherapy infection infections liver liver disease pathology viral hepatitis virus

Editors and affiliations

  • H. C. Thomas
    • 1
  • J. Waters
    • 1
  1. 1.Department of MedicineSt Mary’s Hospital Medical SchoolLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1994
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-8975-0
  • Online ISBN 978-94-011-1428-8
  • Buy this book on publisher's site