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Metal Compounds in Cancer Therapy

  • Simon P. Fricker

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Simon P. Fricker
    Pages 1-31
  3. Lloyd R. Kelland
    Pages 32-45
  4. C. Frank Shaw III
    Pages 46-64
  5. Gianni Sava
    Pages 65-91
  6. Alan J. Crowe
    Pages 147-179
  7. Philippe Collery
    Pages 180-197
  8. John M. C. Gutteridge
    Pages 198-214
  9. Back Matter
    Pages 248-256

About this book

Introduction

The discovery of the antitumour activity of cisplatin in 1965 and its subsequent introduction into clinical trials in 1971 was the catalyst for a major international research effort investigating the potential of metal compounds in cancer therapy. Cisplatin now occupies an important place in the armamentarium of the oncologist due to its effectiveness in the treatment of testicular cancer. A second generation analogue, carbo­ platin, offers reduced toxicity together with therapeutic activity, which gives it a place in the front-line therapy of genitourinary cancers. These and other successes have encouraged the search for novel metal-based drugs for cancer therapy. Research has shown that metal compounds have potential for activity not only as cytotoxic antitumour agents, but also in areas such as adjuvant therapy, diagnosis and immunotherapy. The aim of this book is to review and describe the major achievements and developments arising from this international research effort. The contributing authors come from labora­ tories throughout Europe and America and represent the many disci­ plines characteristic of this research, such as clinical research, pharmacology, tumour biology and inorganic medicinal chemistry.

Keywords

cancer cancer therapy clinical trial imaging research tumor

Editors and affiliations

  • Simon P. Fricker
    • 1
  1. 1.Johnson Matthey Technology CentreReadingUK

Bibliographic information