Genetic factors in coronary heart disease

  • Uri Goldbourt
  • Ulf de Faire
  • Kåre Berg

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 156)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Coronary heart disease in families and populations

  3. Coronary heart disease risk factors and their genetics

    1. Front Matter
      Pages 69-69
    2. D. C. Rao, George P. Vogler
      Pages 71-81
    3. Daniel J. Rader, H. Bryan Brewer Jr.
      Pages 83-103
    4. Melissa A. Austin
      Pages 105-113
    5. Masashi Shiomi, Yoshio Watanabe
      Pages 115-124
    6. William P. Fay, David Ginsburg
      Pages 125-138
    7. Killian Robinson, Kok Soon Tan, Ian M. Graham
      Pages 139-152
    8. Clarence E. Grim, Miguel T. Robinson
      Pages 153-177
    9. Yukio Yamori
      Pages 179-187
    10. Claude Bouchard
      Pages 189-202
    11. Leslie J. Raffel, Tamar Shohat, Jerome I. Rotter
      Pages 203-215
    12. Judith R. Koopmans, Lorenz J. P. van Doornen, Dorret I. Boomsma
      Pages 217-235
  4. Monogenic traits affecting coronary heart disease incidence

    1. Front Matter
      Pages 237-237
    2. Gustav Schonfeld, Elaine S. Krul
      Pages 239-266
    3. Eran Leitersdorf
      Pages 267-273
  5. Molecular approaches to clinical research

  6. Genetic aspects of vessel wall processes

    1. Front Matter
      Pages 329-329
    2. Jeffrey M. Hoeg, Alan T. Remaley
      Pages 351-369
  7. Genetic variation and approaches to clinical research and preventive/public health actions

    1. Front Matter
      Pages 371-371
    2. Thomas G. Pickering, William Gerin
      Pages 385-396
    3. Uri Goldbourt
      Pages 397-408
    4. Roger R. Williams, M. Catherine Schumacher, Paul N. Hopkins, Steven C. Hunt, Lily L. Wu, Sandra J. Hasstedt et al.
      Pages 425-445
  8. Back Matter
    Pages 447-463

About this book


Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors.
This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed.
Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health.


Diabetes biostatistics cardiovascular epidemiology genetic epidemiology methodology

Editors and affiliations

  • Uri Goldbourt
    • 1
  • Ulf de Faire
    • 2
  • Kåre Berg
    • 3
  1. 1.Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research InstituteSheba Medical Center and Tel Aviv UniversityIsrael
  2. 2.Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal MedicineKarolinska HospitalStockholmSweden
  3. 3.Institute of Medical Genetics, Department of Medical GeneticsUllevål University HospitalOsloNorway

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 1994
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-4494-3
  • Online ISBN 978-94-011-1130-0
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site