The Arterial System in Hypertension

  • Michel E. Safar
  • Michael F. O’Rourke

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 144)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Michel E. Safar, Michael F. O’Rourke
    Pages 1-3
  3. Ricky D. Latham, David M. Slife
    Pages 39-53
  4. Colin L. Berry, Jorge A. Sosa-Melgarejo
    Pages 55-72
  5. Marie Christine Mourlon-Le Grand, Bernard I. Lévy
    Pages 73-87
  6. Jean-Baptiste Michel, Jean-François Arnal
    Pages 89-105
  7. René Gourgon, Alain Cohen-Solal
    Pages 155-179
  8. Gérard M. London, Michel E. Safar
    Pages 181-194
  9. Athanase Benetos, Michel E. Safar
    Pages 195-207
  10. Gerard M. London, Bernard I. Lévy
    Pages 209-219
  11. Gérard M. London, Toshio Yaginuma
    Pages 221-237
  12. Back Matter
    Pages 239-240

About this book


MICHEL E. SAFAR and MICHAEL F. O'ROURKE One of the principal problems of hypertension is the precise definition of blood pressure as a cardiovascular risk factor. Clinicians indicate peak systolic pressure and end diastolic pressure in the brachial artery as the principal criteria for blood pressure measurement. Consequently, these values are as indicators for clinical management and therapeutic adjustment. This used methodology, based on indirect blood pressure measurements at the site of the brachial artery relates only to the highest and lowest pressure in that vessel, and does not give any information of the blood pressure curve itself; this carries more information than peak systolic pressure and end diastolic pressure. As a first step in better analysis of the blood pressure curve, research workers in experimental hypertension defined in addition to peak systolic pressure and end diastolic, another blood pressure value, mean arterial pressure, i. e. the average pressure throughout the cardiac cycle, and about which pressure fluctuates. This is the pressure recorded by Hales [1] and by Poiseuille [2] in their pioneering studies. By application of Poiseuille's Law, this definition of mean arterial pressure led to the concept that increased mean arterial pressure (and therefore hypertension) was related, at any given value of cardiac output, to an increase in vascular resistance, i. e. to a reduc­ tion in the caliber of the small arteries.


Angiotensin II blood pressure heart hypertension physiology

Editors and affiliations

  • Michel E. Safar
    • 1
  • Michael F. O’Rourke
    • 2
  1. 1.Broussais-Hôtel DieuParisFrance
  2. 2.University of New South Wales, St. Vincent’s HospitalSydneyAustralia

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 1993
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-4389-2
  • Online ISBN 978-94-011-0900-0
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site