Multiple Drug Resistance in Cancer

Cellular, Molecular and Clinical Approaches

  • Martin Clynes

Table of contents

  1. Front Matter
    Pages i-viii
  2. Ursula A. Germann
    Pages 33-62
  3. Patricia V. Schoenlein
    Pages 63-89
  4. Yuji Heike, Takashi Tsuruo
    Pages 91-107
  5. Augusto Pessina
    Pages 127-135
  6. Glenn A. Hofmann, Michael R. Mattern
    Pages 137-154
  7. Jeffrey A. Moscow, Katharine H. Dixon
    Pages 155-170
  8. James M. Ford, William N. Hait
    Pages 171-212
  9. Martin Clynes, Mary Heenan, Keara Hall
    Pages 231-256
  10. G. Belvedere, E. Dolfini
    Pages 257-264
  11. Marie-Thérèse Dimanche-Boitrel, Carmen Garrido, Bruno Chauffert
    Pages 347-356
  12. Johannes Doehmer, Arnold R. Goeptar, Nico P. E. Vermeulen
    Pages 357-366
  13. Back Matter
    Pages 393-393

About this book


This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.


biochemistry cancer chemistry cytochrome P450 cytogenetics drug drug resistance gene expression genetics molecular genetics protein proteins research resistance tumor

Editors and affiliations

  • Martin Clynes
    • 1
  1. 1.National Cell & Tissue Culture Center/Bioresearch IrelandDublin City UniversityGlasnevin, DublinIreland

Bibliographic information