Pharmacological Control of Calcium and Potassium Homeostasis

Biological, Therapeutical, and Clinical Aspects

  • T. Godfraind
  • G. Mancia
  • M. P. Abbracchio
  • L. Aguilar-Bryan
  • S. Govoni

Part of the Medical Science Symposia Series book series (MSSS, volume 9)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Karen S. De Jongh, Eric I. Rotman, Adrian Sculptoreanu, Brian J. Murphy, Todd Scheuer, William A. Catterall
    Pages 1-8
  3. Qian Chen, Duncan Haynes, Ismail Laher, Cornelis van Breemen
    Pages 9-16
  4. Olaf Pongs, Stefan H. Heinemann, Jens Rettig, Sabine Sewing, Oliver Dolly
    Pages 17-22
  5. Ulrich Quast, Jean-Michel Guillon, Icilio Cavero
    Pages 23-42
  6. Théophile Godfraind, Nicole Morel
    Pages 43-55
  7. Roberto Ferrari, Massimo Benigno, Antonella Boraso
    Pages 57-64
  8. Luiz Belardinelli, Yejia Song
    Pages 65-72
  9. Mikio Nakashima, Michel Félétou, Paul M. Vanhoutte
    Pages 73-83
  10. Gillian Edwards, Arthur H. Weston
    Pages 85-93
  11. M. R. Soma, F. Bernini, A. Corsini, R. Fumagalli, R. Paoletti
    Pages 103-110
  12. JØrgen Fischer Hansen, Lisbeth Tingsted Andersen
    Pages 119-128
  13. Massimo Volpe, Michele Romano, Rosaria Russo, Bruna Gigante, Alessandro F Mele, Speranza Rubattu
    Pages 139-145
  14. Bruno Trimarco, Luigi Argenziano, Gianni Luigi Iovino, Domenico Sarno, Carmine Morisco
    Pages 159-165
  15. Michael Kirchengast, Stefan Hergenröder, Klaus Münter
    Pages 173-179
  16. Luis M. Ruilope, Rafael GarcÞa-Robles
    Pages 181-188
  17. Tibor Kristián, Ken-ichiro Katsura, Bo K. Siesjö
    Pages 199-208
  18. M. Spedding, A. Lombet, C. Jean-Jean, P. Morain, J. Lepagnol
    Pages 209-217
  19. Cesare Fieschi, Cristina Cavalletti, Danilo Toni, Giuliano Sette, Marco Fiorelli, Maria Luisa Sacchetti et al.
    Pages 219-225
  20. Volker A.W. Kreye, Ion Anghelescu, Shunichi Kajioka, Christoph Karle, Dietmar Pfründer
    Pages 247-254
  21. Back Matter
    Pages 271-275

About this book


As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. The present volume provides an update on the basic knowledge, the molecular targets of the two channels, and the importance the drugs that bind them have as pharmacological tools and therapeutic agents. This work was presented at the 6th International Symposium on PHARMACOLOGICAL CONTROL OF CALCIUM AND POTASSIUM HOMEOSTASIS: BIOLOGICAL, THERAPEUTICAL, AND CLINICAL ASPECTS, in Florence (Italy) on October 4-6, 1994. Because of the recent advances in the field, discussions on potassium channels were included for the first time. At least six classes of voltage-dependent calcium channels have been defined based on their physiological and pharmacological properties. Among them, L-type channels, mediating long lasting currents, are better characterized. Calcium homeostasis within the cell is not only regulated by calcium channels; intracellular calcium stores, in particular a pool contained in the lumen of specialized areas of the endoplasmic reticulum, are rapidly exchanged with the cytoplasm and playa key role in the control of calcium homeostasis. This area, however, has not yet been exploited from a therapeutic point of view. Potassium channels are present in virtually every cell type, excitable and nonexcitable, and are distinguished by structural, biophysical, and pharmacological criteria. Different classes including voltage-gated, ligand-gated, AP-sensitive, and G-protein coupled among others, have been defined by their primary regulatory and gating mechanisms.


Nervous System cardiovascular clinical application hypertension pathophysiology physiology

Editors and affiliations

  • T. Godfraind
    • 1
  • G. Mancia
    • 2
  • M. P. Abbracchio
    • 3
  • L. Aguilar-Bryan
    • 4
  • S. Govoni
    • 5
  1. 1.Laboratory of PharmacologyCatholic University of LouvainBrusselsBelgium
  2. 2.Center of Physiology, Hypertension ClinicUniversity of MilanMilanItaly
  3. 3.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  4. 4.Baylor College of MedicineHoustonUSA
  5. 5.Institute of PharmacologyUniversity of PaviaPaviaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 1995
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-4056-3
  • Online ISBN 978-94-011-0117-2
  • Series Print ISSN 0928-9550
  • Buy this book on publisher's site