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Immunological Aspects of Cancer

  • J. E. Castro

Table of contents

  1. Front Matter
    Pages i-ix
  2. P. C. L. Beverley
    Pages 101-122
  3. Suzanne A. Eccles
    Pages 123-154
  4. I. J. Fidler, I. R. Hart
    Pages 183-204
  5. G. Möller, Erna Möller
    Pages 205-217
  6. A. J. Cochran
    Pages 219-266
  7. J. Folkman
    Pages 267-282
  8. J. Shuster, D. M. P. Thomson, P. Gold
    Pages 283-312
  9. M. D. Prager
    Pages 313-355
  10. Tessa E. Sadler, J. E. Castro
    Pages 357-384
  11. C. B. Freeman
    Pages 385-413
  12. J. U. Gutterman, G. M. Mavligit, M. A. Schwarz, E. M. Hersh
    Pages 415-470
  13. Back Matter
    Pages 471-477

About this book

Introduction

An immunological approach to the treatment of cancer has many theoretical features to commend it. There should be specificity, so that tumour cells alone are destroyed whilst normal tissues are unaffected. Provided the tumour is uni­ form and all of the cells have appropriate antigens, every malignant cell should be destroyed and even distant metastases dealt with. So far these speculative advantages are unfulfilled and the initial optimism that surrounded im­ munotherapy has not been sustained. Acceptance of the precepts of tumour im­ munology continues but these disappointing observations had led to increasing scrutiny of certain aspects. The purpose of this chapter is to review the prin­ ciples which underly tumour immunology and immunotherapy, so that the more detailed studies that follow can be considered in perspective. TUMOUR ANTIGENS (Chapter 2) For a tumour to initiate an immunological response, it must possess distinctive antigens. Much of the early work in tumour immunity was confused because it was not appreciated that tumours, like other tissues, exhibit transplan­ tation antigens. Only when syngeneic tumours are used can tumour antigens alone be studied and it was the introduction of inbred mouse strains which allowed Foley in 1953' to produce the first evidence for specific an­ tigenicity of experimental tumours. Demonstration of these antigens requires that pretreatment with syngeneic tumour will influence the growth of a sub­ sequent challenge with the same neoplastic cells.

Keywords

cancer

Editors and affiliations

  • J. E. Castro
    • 1
  1. 1.Royal Postgraduate Medical SchoolLondonUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-010-9418-4
  • Copyright Information Springer Science+Business Media B.V. 1978
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-9420-7
  • Online ISBN 978-94-010-9418-4
  • Buy this book on publisher's site