Clinical Aspects of Albumin

  • S. H. Yap
  • C. L. H. Majoor
  • J. H. M. van Tongeren

Table of contents

  1. Front Matter
    Pages i-xii
  2. H. Bloemendal
    Pages 1-8
  3. D. A. Shafritz, R. K. Strair, S. H. Yap
    Pages 25-48
  4. M. Oratz, M. A. Rothschild, S. S. Schreiber
    Pages 67-80
  5. S. Jarnum, K. B. Jensen
    Pages 81-96
  6. J. H. M. Van Tongeren, O. J. J. Cluysenaer, C. B. H. Lamers, P. H. M. De Mulder, S. H. Yap
    Pages 117-133
  7. J. Gerbrandy, S. J. Smith, H. G. Van Eijk
    Pages 134-148
  8. E. J. Ariëns, A. M. Simonis
    Pages 149-171
  9. H. W. Krijnen
    Pages 172-174
  10. Y. A. Hekster, R. W. M. M. Langenhoff, L. J. B. Zuidgeest, J. C. L. H. Benneker, E. Van Der Kleijn
    Pages 175-184
  11. Back Matter
    Pages 200-203

About this book


Albumin is the most abundant serum protein produced by the liver. In clinical practice the serum level of albumin continues to be used as an important marker of the presence, progress or ofthe improvement of many diseases, even though it is the complex end result of synthesis, degradation a. nd distribution between intra- and extravascular space. The clinical history of albumin began as early as in 1837, when Ancell first recognized "albumen" and noted that this protein is needed for trans­ port functions, for maintaining fluidity of the vascular system and for the prevention of edema. However, the important physiological properties of serum proteins and their role in the regulation ofthe oncotic pressure were demonstrated later by the physiologist E. H. Starling in 1895. In 1917 the clinician A. A. Epstein first described the edema in patients with the nephro­ tic syndrome as being a result of a very low level of serum albumin. Al­ though the determination of serum albumin concentration became more popular after Howe in 1921 introduced the technique of separation of serum globulins from albumin by sodium sulfate, the first preparations of human serum albumin were made available for clinical use in only 1941 by the development of plasma fractionation by Cohn and his coworkers at Harvard Medical School.


Infusion biosynthesis development diseases distribution drug fat liver metabolic disease patients plasma prevention protein proteins transport

Editors and affiliations

  • S. H. Yap
    • 1
  • C. L. H. Majoor
    • 2
  • J. H. M. van Tongeren
    • 2
  1. 1.St. Radboud HospitalUniversity of Nijmegen and Albert Einstein College of MedicineNew YorkUSA
  2. 2.St. Radboud HospitalUniversity of NijmegenNetherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1978
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-9746-2
  • Online ISBN 978-94-009-9744-8
  • Buy this book on publisher's site