Synthetic Substrates in Clinical Blood Coagulation Assays

  • H. R. Lijnen
  • D. Collen
  • M. Verstraete

Part of the Developments in Hematology book series (DIHI, volume 1)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. The Coagulation System

  4. The Fibrinolytic System

  5. General Discussion and Conclusions

    1. Front Matter
      Pages 133-133
    2. H. R. Lijnen, D. Collen, M. Verstraete
      Pages 135-141

About this book


This book contains the proceedings of a symposium on the use of synthetic substrates in clinical blood coagulation assays, which was held at the University of Leuven, Belgium, on March 1st, 1980. This meeting was organized in order to exchange and discuss recent develop­ ments and applications in this field. Advantages and disadvantages of synthetic substrates are discussed, while expert workers report on their practical experience with the use of chromogenic substrates in routine assays for blood coagulation and fibrinolysis. The indications when to perform antithrombin III, a2-antiplasmin, factor X and factor II determinations are discussed. For each of the determinations a critical evaluation of the chromogenic assay as compared to the classical assay is presented. The clinical relevance of these assays for anticoagulated and cirrhotic patients, detection of vitamin K deficiency, monitoring heparin therapy and the fibrinolytic system are discussed. Recent developments in the use of fluorogenic substrates for the assay of low concentrations of fibrin­ olytic activators are presented. Taking into account all practical, medical and economical con­ siderations an answer is prepared to the question "Are synthetic sub­ strates to be recommended for routine use?". To make this symposium useful, rapid publication of the proceedings has been undertaken. We are grateful to the participants in this meeting for their co­ operation and for their willingness to provide manuscripts of their presentations. The manuscripts provided by C. Kluft and H.H.D.M.


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Editors and affiliations

  • H. R. Lijnen
    • 1
  • D. Collen
    • 1
  • M. Verstraete
    • 1
  1. 1.Center for Thrombosis and Vascular Research, Department of Medical ResearchUniversity of LeuvenLeuvenBelgium

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1980
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-8912-2
  • Online ISBN 978-94-009-8910-8
  • Buy this book on publisher's site