Hormones and the Brain

  • David de Wied
  • Pieter A. van Keep

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Receptors and peptidergic pathways in the brain

  3. Hormones and behaviour

    1. Front Matter
      Pages 101-101
    2. D. de Wied
      Pages 103-113
    3. H. M. Van Praag, W. M. A. Verhoeven
      Pages 141-153
    4. R. H. Ehrensing, A. J. Kastin
      Pages 155-165
    5. J. M. van Ree
      Pages 167-173
    6. R. M. Rose
      Pages 175-187
    7. H. Kopera
      Pages 189-203
    8. J. J. Legros, P. Chiodera, C. Mormont, J. Servais, P. Franchimont
      Pages 205-217
  4. Psychopathology as a Consequence of Hormone Dysfunction

    1. Front Matter
      Pages 219-219
    2. I. Munkvad, A. Randrup, R. Fog
      Pages 221-229
    3. L. Terenius
      Pages 231-240
    4. P. W. Gold, F. K. Goodwin, J. C. Ballenger, H. Weingartner, G. L. Robertson, R. M. Post
      Pages 241-252
    5. M. Fink
      Pages 253-261
    6. H. Rigter, J. C. Crabbe
      Pages 263-275
  5. Hormonal Changes in Psychopathology

  6. Back Matter
    Pages 327-337

About this book


During the last decade it has become evident that the brain is an important target for hormones. Although it has been discovered only recently that the brain contains numerous peptide hormones, the role of pituitary and hypo­ thalamic hormones in brain activity has been the subject of basic studies for quite some time. Peptide hormones are involved in mental performance. pain perception, food and water metabolism. sleep. sexual behaviour and nursing behaviour, and disturbances in the hormonal climate of the brain may be associated with psychopathology. cognitive disturbances and. possibly. addic­ tion. The clinical influence of neurohypophysial hormones and their frag­ ments is studied today on learning and memory. on inadequate behaviour and addiction, in Parkinson's disease. Lesch-Nyhan syndrome. depression and schizophrenia. Fragments of adrenocorticotrophin have been shown to affect motivation, concentration and attention. and neuropeptides derived from ~-lipotrophin are probably involved in psychopathology. Thyrotrophin­ releasing hormone has been implicated in depression. and lutein-releasing hormone in sexual disturbances. In spite of the impressive experimental data; clinical results to date have been controversial and. to some extent. anecdotal. In some cases they have been exciting. and in others disappointing. It was against this background that the International Health Foundation decided to organize and sponsor their workshop on 'The brain as an endo­ crine target organ in health and disease' at which the papers appearing in this book were presented.


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Authors and affiliations

  • David de Wied
    • 1
  • Pieter A. van Keep
    • 2
  1. 1.Rudolf Magnus Instituut voor Farmacologie, Medische FaculteitRijksuniversiteit UtrechtUtrechtThe Netherlands
  2. 2.International Health FoundationGenèvaSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1980
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-8711-1
  • Online ISBN 978-94-009-8709-8
  • Buy this book on publisher's site