Advertisement

The Biological Effects of Glutamic Acid and Its Derivatives

  • Editors
  • V. A. Najjar

Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 1)

Table of contents

  1. Front Matter
    Pages i-4
  2. Michel Baudry, Gary Lynch
    Pages 5-18
  3. John J. McGuire, Joseph R. Bertino
    Pages 19-48
  4. M. J. W. Brennan, R. C. Cantrill
    Pages 49-58
  5. Mary Lynn Fink, J. E. Folk
    Pages 59-67
  6. K. R. Jessen
    Pages 69-76
  7. Tage Honoré, Povl Krogsgaard-Larsen, Jan J. Hansen, Jørn Lauridsen
    Pages 123-128
  8. Povl Krogsgaard-Larsen, Erik Falch
    Pages 129-146
  9. E. K. Michaelis, M. L. Michaelis, H. H. Chang, R. D. Grubbs, D. R. Kuonen
    Pages 163-179
  10. George N. Abraham, David N. Podell
    Pages 181-190
  11. John P. Burnier, Marianne Borowski, Barbara C. Furie, Bruce Furie
    Pages 191-207
  12. David J. Cichowicz, Siang K. Foo, Barry Shane
    Pages 209-228
  13. Jang-Yen Wu, Christopher Brandon, Y. Y. Thomas Su, Dominic M. K. Lam
    Pages 229-238
  14. Vivian I. Teichberg, Ora Goldberg, Alberto Luini
    Pages 281-295
  15. Roy L. Kisliuk
    Pages 331-345
  16. P. A. Briley, M. T. Filbin, G. G. Lunt, P. D. Turner
    Pages 347-356

About this book

Introduction

the GABA increase takes place and (2) the area of the brain that may mediate the anticonvulsant Investigation of the physiology, biochemistry, activity. Three compounds that increase brain pharmacology and anatomy of GAB A and GABA­ GABA by distinct mechanisms were used in these containing neural systems, continues to reveal the studies: di-n-propylacetate (DPA, sodium val­ rich complexities associated with this neuroactive proate, Depakene(R)), amino-oxyacetic acid amino acid (see recent symposia 1,2,3). Advances (AOAA) and y-vinyl GABA (GVG). in the pharmacology of GABA-mimetic agents In the next sections, the metabolism of GABA have resulted in the development of compounds and a brief historical account of the relationship that can selectively activate GABA receptors (4,5, between GABA and anticonvulsant activity are 6, 7), inhibit the synthetic and degradative enzymes outlined followed by a discussion ofthe biochemical for GABA (8, 9) or affect the neuronal and glial and pharmacological effects of the three drugs. In uptake processes for GABA (10, 11). This has particular, the literature pertaining to the suppres­ already had a significant impact on our under­ sion of seizures and the correlation between anti­ standing of the role of GABA in convulsions and a convulsant action and increases in brain G ABA will range of other CNS functions including feeding be examined. (12), cardiovascular control (13), motor activity (14) and release of pituitary hormones (15). Before 1.

Keywords

Amino acid Aspartat Glutamat biochemistry translation

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-8027-3
  • Copyright Information Springer Science+Business Media B.V. 1981
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-8029-7
  • Online ISBN 978-94-009-8027-3
  • Buy this book on publisher's site