Cardiac Rate and Rhythm

Physiological, Morphological and Developmental Aspects

  • Lennart N. Bouman
  • Habo J. Jongsma

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 17)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Introduction

    1. Lennart N. Bouman, Habo J. Jongsma
      Pages 1-3
  3. Fundamentals of Pacemaker Activity

  4. Interaction of Pacemaker Cells

    1. Front Matter
      Pages 167-168
    2. Silvio Weidmann
      Pages 169-177
    3. Walmor C. De Mello
      Pages 179-194
    4. Feliksas F. Bukauskas, Aron M. Gutman, Klemensas J. Kisunas, Romualdas P. Veteikis
      Pages 195-216
    5. Daniel Gros, Ian Lee, Cyril E. Challice
      Pages 243-264
    6. David E. Clapham, Robert L. DeHaan
      Pages 265-281
    7. Michiel J. Janse, Frans J. L. van Capelle
      Pages 297-320
  5. Establishment of Cardiac Rhythm

    1. Front Matter
      Pages 321-321
    2. Robert L. DeHaan
      Pages 323-361
    3. Dirk L. Ypey, Wilbert P. M. Van Meerwijk, Robert L. DeHaan
      Pages 363-395
  6. Neural Control of Rate and Rhythm

    1. Front Matter
      Pages 471-471
    2. Lennart N. Bouman, Tobias Op ‘t Hof, Albert J. C. Mackaay, Wim K. Bleeker, Habo J. Jongsma
      Pages 473-483
    3. Wolfgang Osterrieder, Qin-fei Yang, Wolfgang Trautwein
      Pages 485-505
    4. Albert J. C. Mackaay, Tobias Op ‘t Hof, Wim K. Bleeker, Habo J. Jongsma, Lennart N. Bouman
      Pages 507-523
    5. Felix I. M. Bonke, Maurits A. Allessie, Victor A. J. Slenter, Roland Kengen
      Pages 525-542
    6. E. Neil Moore, Joseph F. Spear, Kenneth D. Kronhaus
      Pages 543-561
    7. Jose Jalife, Philip Fraccola, Gordon K. Moe
      Pages 577-603
    8. Michel Lazdunksi, Jean-Francois Renaud, Georges Romey, Michel Fosset, Jacques Barhanin, Alain Lombet
      Pages 605-629
  7. Back Matter
    Pages 653-682

About this book


In the denervated state the mammalian heart, both in vivo and in vitro, is excited at very regular intervals, the coefficient of variance of the interbeat intervals not exceeding 2%. The pacemaker that is the source of this regular ex­ citation is localised normally within the sinus node (" sino-atrial node " node of Keith and Flack), a most intriguing small piece of tissue in the caval corner of the right atrium. A small portion of this node containing a group of probably only a few thousands of cells fires spontaneously, that means without any exter­ nal influence to trigger their activity. The so called pacemaker cells do this by letting their membrane potential fall to the level where an action potential will start which subsequently activates surrounding cells to fire an action po­ tential. The first question which is tackled in this book is which processes underly this spontaneous diastolic depolarization. This is discussed in section I, concerning the fundamental properties of pacemaker cells with special refer­ ence to ionic membrane currents. Although views still quite differ about the exact nature of the membrane processes that cause the automatic pacemaker dis­ charge there is agreement that diastolic depolarization is brought about by the interaction of a number of ionic current systems, including both inward and out­ ward going currents.


drugs heart heart rate membrane pacemaker

Editors and affiliations

  • Lennart N. Bouman
    • 1
  • Habo J. Jongsma
    • 1
  1. 1.Department of PhysiologyUniversity of AmsterdamThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1982
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-7537-8
  • Online ISBN 978-94-009-7535-4
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site