Tumor Invasion and Metastasis

  • L. A. Liotta
  • I. R. Hart

Part of the Developments in Oncology book series (DION, volume 7)

Table of contents

  1. Front Matter
    Pages I-X
  2. Tumor-Host Interactions in Metastasis

  3. Models of Tumor Invasion

  4. Interaction of Tumor Cells with Connective Tissue

    1. J. C. Murray, L. A. Liotta, V. P. Terranova
      Pages 309-318
    2. L. A. Liotta, S. Garbisa, K. Tryggvason
      Pages 319-333
    3. D. E. Ingber, J. D. Jamieson
      Pages 335-357
    4. J. C. Barrett, S. Sheela
      Pages 359-374
    5. R. H. Goldfarb
      Pages 375-390
  5. Clinical Topics in Metastases

    1. E. V. Sugarbaker, D. N. Weingrad, J. M. Roseman
      Pages 427-465
    2. P. S. Dickman, T. J. Triche
      Pages 467-494
    3. E. W. Chu, S. E. Martin
      Pages 495-510
  6. Back Matter
    Pages 531-534

About this book


The clinical significance of tumor spread has always been appreciated. Yet, in spite of the pioneering work and outstanding contributions of investigators such as D. Coman, H. Green, B. Fisher, S. Wood and I. Zeidman, studies on metastasis rarely achieved the popularity afforded to more esoteric areas of tumor biology. Tumor dissemination, occurring as it does in a responding host and being composed of a series of dynamic int~ractions, is a highly complex phenomenon. Few investigators were brave enough to attempt to unravel the mechanisms involved. Paradoxically, this very complexity may have contributed, in part, to the recent upsurge of interest in metastasis research. More and more researchers are becoming fascinated by the complexities of the cellular interactions involved in tumor spread. Accompanying this intellectual stimulation have been technological advances in related fields which allow the derivation of new model systems. The mechanisms of metastatic spread are increasingly amenable to both the reductionist and holistic approaches and it is the purpose of this volume to present many of these model systems while emphasizing the intricacy and complexity of the processes they mimic. We have attempted to emphasize two topics not previously covered in depth in previous books on metastases. These are in vitro models of invasion and in­ teractions of tumor cells with connective tissue.


metastasis tumor

Editors and affiliations

  • L. A. Liotta
    • 1
  • I. R. Hart
    • 2
  1. 1.National Cancer InstituteBethesdaUSA
  2. 2.Frederick Cancer Research CenterFrederickUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1982
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-7513-2
  • Online ISBN 978-94-009-7511-8
  • Buy this book on publisher's site