Advances in Research on Cholera and Related Diarrheas

  • S. Kuwahara
  • N. F. Pierce

Part of the New Perspectives in Clinical Microbiology book series (NPCM, volume 6)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Immunology and Vaccine Development

    1. Front Matter
      Pages 1-1
    2. Dolores G. Evans, Francisco F. J. de la Cabada, Doyle J. Evans Jr.
      Pages 3-5
    3. Nathaniel F. Pierce, William C. Cray Jr., John B. Sacci Jr.
      Pages 41-48
    4. Myron M. Levine, Robert E. Black, Mary Lou Clements, Charles R. Young, Takeshi Honda, Richard Finkelstein
      Pages 49-55
  3. Bacteriology and Virulence Factors

    1. Front Matter
      Pages 57-57
    2. Yasuo Kudoh, Masaaki Tsuno, Shigeru Matsushita, Sumio Yamada, Kenji Ohta, Senzo Sakai et al.
      Pages 75-86
    3. D. E. Lockwood, S. H. Richardson, A. S. Kreger, M. Aiken, B. McCreedy
      Pages 87-99
    4. Makoto Ohashi, Takeshi Terayama, Hiroshi Ushioda, Yasuo Kudoh, Masaaki Tsuno, Shigeru Matsushita et al.
      Pages 113-120
    5. Richard A. Finkelstein, Larry F. Hanne
      Pages 121-125
    6. Eiji Tokunaga, Toyoharu Muraoka, Shunsuke Akiyama, Kazusuke Kudo, Nobuya Ohtomo
      Pages 127-134
  4. Clinical Studies

    1. Front Matter
      Pages 145-145
    2. Charles D. Ericsson, Herbert L. DuPont, Peggy Sullivan, Emma Galindo, Dolores G. Evans, Jean Hinlicky et al.
      Pages 147-149
    3. Tetsuo Morishita, Rafiqul Islam, Pradip K. Bardhan, Yoshio Munakata, Toshifumi Hibi, Hitoshi Asakura et al.
      Pages 151-157
    4. Robert J. Rothbaum, A. James McAdams, Ralph A. Giannella, D. B. Shah, Pamela Smith, John C. Partin
      Pages 159-167
  5. Genetics

  6. Enterotoxins

    1. Front Matter
      Pages 217-217
    2. Takeshi Yokota, Teruyo Ito, Shogo Kuwahara
      Pages 219-225
    3. Yutaka Zinnaka, Sumiaki Tsuru, Nobuya Ohtomo, Toyoharu Muraoka, Kenji Takeya
      Pages 227-231
    4. Koichiro Yamamoto, Yoshifumi Takeda, Toshio Miwatani, John P. Craig
      Pages 233-246
    5. Takeshi Honda, Sekiko Taga, Michiko Arita, Yoshifumi Takeda, Toshio Miwatani
      Pages 279-284
    6. Randall K. Holmes, Edda M. Twiddy, Michael G. Bramucci
      Pages 293-300
  7. Back Matter
    Pages 301-306

About this book


The United States-Japan Cooperative Medical Science Program was initiated in 1965 by joint agreement between the President of the United States and the Prime Minister of Japan. The purpose of the Program was to promote cooperative biomedical research between the two countries, especially on health problems of recognized impor­ tance in Asia. Cholera was designated as one topic of mutual interest. Panels of scientists from each country were formed, and these met to select priority areas for research. The Cholera Panels initially defined two major goals: 1) improved and simplified therapy for cholera, and 2) better methods for immunization. Progress in the pursuit of these goals led to the recognition that bacteria other than Vibrio cholerae are also important causes of acute dehydrating diarrhea which resembles cholera in its manifestations and patho­ genesis; most notable among these are enterotoxinogenic strains of Escherichia coli. Accordingly, panel guidelines were expanded to include all diarrheal diseases that involve fluid loss caused by an enterotoxin. More recently, studies have shown that vibrios, including V. cholerae, have a distinct environmental life cycle that is probably an impor­ tant factor in the epidemiology of vibrio infections. For this reason, the panel guidelines were again expanded to include studies on the environmental ecology of vibrios. A major project of the Joint Cholera Panels has been the organization and spon­ sorship of an annual conference on cholera and related diarrheal diseases.


antibody antigen bacteriology cell gene genetics immunology infection toxin vaccine

Editors and affiliations

  • S. Kuwahara
    • 1
  • N. F. Pierce
    • 2
  1. 1.Department of MicrobiologyToho UniversityTokyoJapan
  2. 2.Baltimore Hospitals and Johns Hopkins University School of MedicineBaltimoreUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1983
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-6737-3
  • Online ISBN 978-94-009-6735-9
  • Buy this book on publisher's site