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Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions

  • Théophile Godfraind
  • Arnold G. Herman
  • Donald Wellens
Book

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 40)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Introductory considerations

  3. Calcium entry blockers and peripheral circulatory function

  4. Calcium entry blockers and myocardial function

  5. Calcium entry blockers and cerebral function

    1. Front Matter
      Pages 205-205
    2. B. C. White, C. D. Winegar, P. J. Hoehner, D. S. Gadzinski, T. Hoehner, J. Trombley Jr.
      Pages 221-239
  6. Calcium entry blockers in hypertension treatment

  7. Concluding remarks

  8. Back Matter
    Pages 313-322

About this book

Introduction

2 The free internal Ca+ concentration in human red cells is set according to the leak­ 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca­ 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady­ 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con­ 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec­ 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra­ tion is ;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).

Keywords

angina pectoris arterial pressure cardiovascular hemodynamics hypertension

Editors and affiliations

  • Théophile Godfraind
    • 1
  • Arnold G. Herman
    • 2
  • Donald Wellens
    • 3
  1. 1.Laboratoire de Pharmacodynamie Générale et de PharmacologieUniversité Catholique de LouvainBrusselsBelgium
  2. 2.Department of MedicineUniversity of AntwerpWilrijkBelgium
  3. 3.Janssen PharmaceuticaBeerseBelgium

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-6033-6
  • Copyright Information Springer Science+Business Media B.V. 1984
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-6035-0
  • Online ISBN 978-94-009-6033-6
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site