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Receptor-Mediated Endocytosis

  • P. Cuatrecasas
  • T. Roth

Part of the Receptors and Recognition book series (RERE, volume 15)

Table of contents

  1. Front Matter
    Pages i-x
  2. Carol D. Linden, Thomas F. Roth
    Pages 19-44
  3. Ronald D. Vale, Charles E. Chandler, Arne Sutter, Eric M. Shooter
    Pages 83-118
  4. John Lenard, Douglas K. Miller
    Pages 119-138
  5. Philip Stahl
    Pages 139-165
  6. Sjur Olsnes, Kirsten Sandvig
    Pages 187-236
  7. John W. Woods, Thomas F. Roth
    Pages 237-272
  8. Back Matter
    Pages 301-304

About this book

Introduction

This volume focuses exclusively on those endocytic processes that sequester proteins by a selective, receptor-mediated mechanism. In such an endocytic process, cell surface receptors specifically bind protein ligands and localize them to specialized invaginations of the plasma membrane. These regions are coated pits, so named because they are lined on the cytoplasmic face with an ordered array of the protein, clathrin. It is this 'coat' which provides their characteristic electron microscopic image. Subsequently, these regions pinch off to form coated vesicles which rapidly lose their 'coat' and then fuse with other organelles or the plasma membrane. The hallmarks of ,this process are the specific receptors, coated pits, coated vesicles and an ordered sequence of transit events leading to delivery to selected locations. Receptor recognition, specific disposition of the endocytosed ligand and the existence of recep­ tor-ligand complexes at highest density in coated pits define the process as selective and concentrative. This topic has received ever increasing attention during the past few years. The evolving mechanisms are especially exciting because they come at a time when the conventional views based on thermodynamic arguments suggest that proteins should not be able to cross into the cell. Receptor-mediated endocytosis, however, reconciles the view that biological membranes should be impervious to macromolecules with the evidence that certain mac­ romolecules do gain entrance into the cell. During the last few years this field has been stimulated by studies on the uptake and processing of low density lipoproteins (LDL) by cells.

Keywords

Organelle growth factor lipoprotein membrane protein research

Editors and affiliations

  • P. Cuatrecasas
    • 1
  • T. Roth
    • 2
  1. 1.Wellcome Research LaboratoriesResearch Triangle ParkUSA
  2. 2.University of Maryland Baltimore CountyCatonsvilleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-5975-0
  • Copyright Information Springer Science+Business Media B.V. 1983
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-5977-4
  • Online ISBN 978-94-009-5975-0
  • Buy this book on publisher's site