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Histocompatibility Antigens

Structure and Function

  • P. Parham
  • J. Strominger

Part of the Receptors and Recognition book series (WOCS)

About this book

Introduction

The Major Histocompatibility Complex (MHC) was discovered as a con­ sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans­ planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A.

Keywords

Plantation Plasma breeding evolution experiment genes growth immune response immunology membrane mouse protein skin tissue tumors

Editors and affiliations

  • P. Parham
    • 1
  • J. Strominger
    • 2
  1. 1.Stanford University School of MedicineUSA
  2. 2.Harvard UniversityUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-5894-4
  • Copyright Information Springer Science+Business Media B.V. 1982
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-5896-8
  • Online ISBN 978-94-009-5894-4
  • Buy this book on publisher's site