Fundamental Fault in Hypertension

  • Mohinder P. Sambhi

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 36)

Table of contents

  1. Front Matter
    Pages I-XII
  2. The Preamble

    1. Front Matter
      Pages 1-1
    2. Thomas G. Pickering
      Pages 19-23
    3. Arthur C. Guyton, Thomas E. Lohmeier, John E. Hall, Manis J. Smith, Philip R. Kastner
      Pages 35-61
    4. W. H. Birkenhäger, P. W. De Leeuw
      Pages 62-65
  3. How Important is the Salt Intake?

    1. Front Matter
      Pages 67-67
  4. The Central Role of the Kidney

    1. Front Matter
      Pages 83-83
    2. F. J. Haddy, M. B. Pamnani, D. L. Clough
      Pages 85-104
    3. P. Mason, D. G. Beevers, C. Beretta-Piccoli, J. J. Brown, A. M. M. Cumming, D. L. Davies et al.
      Pages 105-116
  5. A Defect in Cell Membrane Permeability

    1. Front Matter
      Pages 117-117
    2. David F. Bohr
      Pages 119-132
  6. The Antihypertensive Hormones of the Kidney

    1. Front Matter
      Pages 145-145
    2. E. E. Muirhead, J. A. Pitcock, W. A. Rightsel, P. S. Brown, M. F. Hall, B. Brooks
      Pages 147-157
    3. Oscar A. Carretero, Alfonso G. Scicli
      Pages 158-174
  7. The Role of the Central Nervous System: Mediation or Initiation?

    1. Front Matter
      Pages 175-175
    2. Giuseppe Mancia, Alberto Zanchetti
      Pages 190-206
    3. L. T. Mahoney, J. R. Haywood, R. Correy, N. P. Patel, A. K. Johnson, M. J. Brody
      Pages 207-212
    4. Walter Lovenberg, Donald Kuhn, Judith Juskevich
      Pages 213-227
    5. Wybren de Jong, Dirk H. G. Versteeg
      Pages 228-234
    6. Giuseppe Mancia, Alberto Ferrari, Luisa Gregorini, Gianfranco Parati, Piero Cioffi, Marco Di Rienzo et al.
      Pages 235-250
  8. Altered Hemodynamics: A Cause or a Consequence?

    1. Front Matter
      Pages 261-261
    2. Robert C. Tarazi
      Pages 276-295
    3. Rosemary D. Bevan, John A. Bevan
      Pages 296-306
  9. How is the Renin System Involved?

    1. Front Matter
      Pages 307-307
    2. P. Lijnen, R. Fagard, J. Staessen, L. Verschueren, A. Amery
      Pages 319-330
    3. Mohinder P. Sambhi
      Pages 341-346

About this book


The fundamental fault in hypertension is unknown. Calling it a fundamental fault, indeed, tacitly begs the question: Is there one fundamental fault, or are there several that are interlinked or interdependent? A simple yes or no answer cannot be offered. This volume is not designed to survey the up-to-date recent advances in research on hypertension, nor intended to provide provisional an­ swers to the so many unknowns in this topic. It is, in fact, an attempt to articulate questions that are worth asking, given the license of an unhibited, albeit disci­ plined, inquiry. The range of expression varies from dogmatic opinion to a declared speculation. Is the primary abnormality an excessive sodium and reduced potassium intake over generations? Or is it hormonal excess, deficiency, imbalance or altered synthesis of abnormal forms? Does the nervous system playa role of active initiation or only of passive maintenance in the genesis of hypertension? Is the heart only a pump acting in concert with the happenings to the vasculature trying to provide adequate flow in the face of vasconstriction induced by neural or humoral factors, or does it sometimes become the culprit by pumping blood flow in excess of demand and thus initiating hypertrophic changes in blood vessels, or by assuming the role of an endocrine organ and being the source of a hormone with influence on cellular transport of sodium and on vasomotor tone? Is an elusive and mysterious fault in the kidney, the primary basis of all of the above


arterial pressure blood pressure heart hemodynamics hypertension

Editors and affiliations

  • Mohinder P. Sambhi
    • 1
    • 2
  1. 1.Division of Hypertension, Department of MedicineUCLASepulvedaUSA
  2. 2.San Fernando Valley Medical ProgramVeterans Administration Medical CenterSepulvedaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1984
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-9006-3
  • Online ISBN 978-94-009-5678-0
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site