Thromboplastin Calibration and Oral Anticoagulant Control

  • A. M. H. P. van den Besselaar
  • H. R. Gralnick
  • S. M. Lewis

Part of the Developments in Hematology and Immunology book series (DIHI, volume 8)

Table of contents

  1. Front Matter
    Pages I-XI
  2. E. A. Loeliger, A. M. H. P. Van Den Besselaar
    Pages 1-9
  3. T. B. L. Kirkwood
    Pages 11-23
  4. E. A. Van Der Velde
    Pages 25-39
  5. J. A. Tomenson
    Pages 87-108
  6. A. M. H. P. Van Den Besselaar, E. A. Van Der Velde
    Pages 127-149
  7. B. Mcd. Duxbury
    Pages 195-196
  8. Back Matter
    Pages 259-263

About this book


This volume contains all relevant information discussed in a Workshop on thromboplastin calibration held in Leiden, The Netherlands on July 1, 1983. The Workshop was an initiative of the Dutch foundation for a Reference Laboratory for Anticoagulant Control (RELAC) and it was organized by the Boerhaave Committee for postgraduate teaching of the Faculty of Medicine of the University of Leiden. The Workshop was held under the auspices of five organizations i. e. the European Community Bureau of Refer­ ence (BCR) , the European Committee for Clinical Laboratory Standards (ECCLS), the International Association of Biological Standardization (lABS), the International Committee for Standar­ dization in Haematology (ICSH), ·and the International Committee on Thrombosis and Haemostasis (ICTH). The aim of the Workshop was to discuss and develop a method for calibration of reagents, i. e. thromboplastins and/or plasmas used for the prothrombin time. During the Workshop three recent thromboplastin calibration studies were discussed, the results of which are presented in chapters 4, 7 and 9. These studies were carried out on the basis of a new calibration model developed by experts working with BCR and WHO. The usefulness of this model and the standardization system based on it is the leading thread running through this volume. Statisticians and clinicians discuss the results from a scientific point of view. Thromboplastin manufacturers, for whom especially the use of the model and the system is intended, discuss the matter also from an economic and legal point of view.


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Authors and affiliations

  • A. M. H. P. van den Besselaar
    • 1
  • H. R. Gralnick
    • 2
  • S. M. Lewis
    • 3
  1. 1.Reference Laboratory for Anticoagulant ControlLeiden University HospitalLeidenThe Netherlands
  2. 2.Hematology Service, Clinical CenterNational Institutes of HealthBethesdaUSA
  3. 3.Department of HematologyRoyal Postgraduate Medical School, Hammersmith HospitalLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1984
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-9005-6
  • Online ISBN 978-94-009-5676-6
  • Buy this book on publisher's site