Minimal Residual Disease in Acute Leukemia

  • B. Löwenberg
  • A. Hagenbeek

Part of the Developments in Oncology book series (DION, volume 19)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Detection of Minimal Residual Disease in Acute Leukemia

  3. Treatment of Minimal Residual Disease in Acute Leukemia: Chemotherapy

  4. Autologous Bone Marrow Transplantation in the Treatment of Acute Leukemia

    1. Patrick J. Stiff, Thomas P. U. Wustrow, Alan R. Koester, Michael F. Derisi, Bayard D. Clarkson
      Pages 183-196
    2. Karel A. Dicke, Christopher H. Poynton, Christoher L. Reading
      Pages 209-221
    3. Ellen S. Vitetta, Jonathan W. Uhr
      Pages 223-232
    4. S. Thierfelder, B. Netzel, G. Hoffmann-Fezer, B. Kranz, J. Haas
      Pages 241-253
    5. S. E. Sallan, R. C. Bast Jr, J. M. Lipton, J. Ritz
      Pages 255-264
    6. A. K. Burnett, P. Tansey, M. Alcorn, C. R. J. Singer, G. A. McDonald, A. G. Robertson
      Pages 265-277
    7. Bob Löwenberg, Johan Abels, Dirk W. van Bekkum, Gorda Dzoljic, Anton Hagenbeek, Willem D. H. Hendriks et al.
      Pages 279-285
    8. A. H. Goldstone, D. C. Linch, C. C. Anderson, M. Jones, S. P. Closs, J. C. Cawley et al.
      Pages 287-291
  5. Allogeneic Bone Marrow Transplantation in the Treatment of Acute Leukemia

  6. Comparative Evaluation of Chemotherapy and Bone Marrow Transplantation in the Treatment of Acute Leukemia

    1. H. J. Weinstein, R. J. Mayer, F. S. Coral, H. E. Grier, R. D. Gelber, D. S. Rosenthal et al.
      Pages 347-357
    2. H. D. Preisler, A. Raza, N. Azarnia, G. Browman
      Pages 359-377
  7. Back Matter
    Pages 397-401

About this book


The objective of the treatment of acute leukemia involves the eradication of all neoplastic cells, including the last one. Ideally, treatment should be controlled by monitoring cell kill. If the last cells could be discovered and their biological properties be determined, the qualitative and quantitative effects of treatment should be directly evaluable. This should ultimately permit a calculated tumor cell reduction thereby avoiding overtreatment and excessive toxicity and thus providing a basis for individualized antileukemic treatment. In recent years several new developments have contributed to the selective discovery of minimal numbers of leukemic cells which are hidden among the normal cells in the marrow cavities. These methods are the first steps to the realization of the therapeutic goals indicated above. They include the production and ap­ plication of monoclonal antibodies against differentiation antigens on the cell sur­ face, the use of pulse cytophotometry - and cell sorter techniques, the employment of cytogenetics, the development of culture techniques for selective growth of precursor cells and several others. These methodologies offer prospects for refined diagnosis and, as far as the elimination of leukemic cells is concerned, the further development of autologous bone marrow transplantation. Eliminating tumor cells from autologous grafts requires the detailed knowledge of the cellular inter­ relationships within the neoplasm so that the neoplastic cells responsible for tumor propagation are specifically removed. Recognition and characterization of the clonogenic cells of the neoplasm should then lead to determining their sensitivity to the therapeutic agents which are clinically applied.



Editors and affiliations

  • B. Löwenberg
    • 1
  • A. Hagenbeek
    • 1
  1. 1.The Dr Daniël den Hoed Cancer CenterRotterdam Radio-Therapeutic InstituteRotterdamThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 1984
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-9002-5
  • Online ISBN 978-94-009-5670-4
  • Buy this book on publisher's site