Mononuclear Phagocytes

1. Interactions of Complement with Membranes of Mononuclear Phagocytes

   1. Uptake and degradation of the C1q subcomponent of complement by adherent guinea pig peritoneal macrophages

      • M. R. Daha, R. Veerhuis, L. A. van Es

      Pages 173-181

   2. Regulation of the function of receptors for C3b and C3bi on human mononuclear phagocytes by receptors for other ligands

      • S. D. Wright, S. C. Silverstein

      Pages 183-191

   3. Role of macrophage-complement receptors and macrophage complement uptake of zymosan

      • R. A. B. Ezekowitz, R. B. Sim, S. Gordon

      Pages 193-198

2. In Vivo Kinetics and in Vitro Growth of Mononuclear Phagocytes

   1. Front Matter

      Pages 199-199

      PDF

   2. New perspectives on the kinetics of mononuclear phagocytes

      • R. van Furth, M. M. C. Diesselhoff-den Dulk, W. Sluiter, J. T. van Dissel

      Pages 201-210

   3. The origins and turnover kinetics of limbocytes

      • C. W. Pugh, G. G. MacPherson

      Pages 211-220

   4. Origin of osteoclasts from bone marrow mononuclear phagocytes

      • E. H. Burger, J. W. M. van der Meer, F. P. van de Wijngaert, R. van Furth

      Pages 221-231

   5. Mononuclear phagocyte progenitors and growth factors

      • L. J. Guilbert

      Pages 233-242

   6. Proliferation and differentiation of mononuclear phagocytes in vitro

      • J. W. M. van der Meer, J. S. van de Gevel, R. de Water, L. A. Ginsel, C. H. Wouters, W. Th. Daems et al.

      Pages 243-254

   7. Clonal analysis of bone marrow and macrophage cultures

      • C. C. Stewart, E. B. Walker, C. Johnson, R. Little

      Pages 255-266

3. Secretion of Products by Mononuclear Phagocytes

   1. Front Matter

      Pages 267-267

      PDF

   2. Control of apolipoprotein E secretion by macrophages

      • Z. Werb, J. R. Chin, R. Takemura, S. M. Frisch, R. L. Oropeza, D. F. Bainton

      Pages 269-278

   3. The secretion of lipoprotein lipase by mononuclear phagocytes

      • E. M. Mahoney, J. C. Khoo, J. L. Witztum, D. Steinberg

      Pages 279-285

   4. Autoregulatory effects of interleukin 1 on human monocytes

      • J. J. Oppenheim, K. Onozaki, K. Matsushima

      Pages 287-293

   5. Macrophage elastase: regulatory consequences of the proteolysis of non-elastin tissue substrates

      • M. J. Banda, E. J. Clark, Z. Werb

      Pages 295-301

   6. Determinants of generation and structural heterogeneity of fibroblast-activating principles of human mononuclear phagocytes

      • J. G. Dohlman, W. J. Goetzl

      Pages 303-309

   7. Signal-response coupling in the arachidonic acid cascade of macrophages

      • A. A. Aderem, W. A. Scott, Z. A. Cohn

      Pages 311-318

   8. Influence of macrophage products on enzyme and prostaglandin E2 release by chondrocytes

      • J. Schnyder, V. Evêquoz, U. Trechsel, M. Baggiolini

      Pages 319-326

4. Mobilization and Chemotaxis of Mononuclear Phagocytes

   1. Front Matter

      Pages 327-327

      PDF

   2. Macrophage movements

      • J. H. Hartwig, T. P. Stossel

      Pages 329-336

Sixteen years have passed since the first Leiden Conference on Mononuclear Phagocytes. That first meeting led to new nomenclature, i. e. , the Mononuclear Phagocytes System (MPS), which was published in the Bulletin of the World Health Organization (R. van Furth, et aI. , Bull. WHO, 1972, 46: 845-852). The paradigm of the MPS has the advantage of being much more consistent than the Reticuloendothelial System (RES) (L. Aschoff, Ergebn. Inn. Med. Kinderheilk. 1924, 26:1), because cells with similar characteristics can be classified in the same category. The essence ota new concept is, according to Popper, that it must be susceptible to falsification. This has been attempted several times for the MPS by those who adhere to the RES. However, in biology no one can be certain of truth. Any theory must be based on experimental observations and/or theoretical consider­ ations and both should be presented in such a way that others can try to refute it, then or later. One may have a theoretical or a pragmatic preference for a theory which at a given time is regarded as possibly truc, but later it may be shown to be false. In other words, what we present in this volume is regarded as true at this moment, but others may consider it as not true and try to disprove it. Controversies often stimulate new research.

• Antigen
• T cell
• bacteria
• blood
• cytotoxicity
• immunoglobulin
• infection
• infections
• lymphocytes
• macrophages
• malaria
• molecular biology
• parasite
• pathology
• physiology

`This book comprises the proceedings of the fourth Leiden conference... Anybody with more than a passing interest in mononuclear phagocyte cells will want to have these proceedings available for consultation. ...this is a book that should be available in every pathology department where there is an interest in these cells.'
The Journal of Clinical Pathology (July 1986)
`These two large volumes contain the proceedings of the Third Conference on Mononuclear Phagocytes held in Leiden in September 1978. They contain a wealth of material which will be of value to those working with monocytes. These books contain papers on the structure, cytochemistry, origin and maturation, function and plasma membranes of the monocyte, their antimicrobial role, and role in the immune response. It should prove valuable as a source of reference and information in this important developing field.'
British Journal of Haematology, 47 (1981)
`...containing the meeting discussions as well as the reports, these proceedings surely embrace the 1978 'state of knowledge' with respect to the mononuclear phagocytic systems.'
Experimental Hematology, 9:1 (1981)
`The reticuloendothelial system died in Leiden in 1969 at the hands of Ralph van Furth and from iets ashes sprang the mononuclear phagocytes system. This massive two volume proceedings from the 3rd Leiden conference held in 1978 is a tribute to the vigour of this new phoenix and clearly documents its explosive growth. Nearly two thousand pages of erudite and informative papers and reviews describing the functional properties of macrophages are enclosed... The contents are entirely comprehensive covering a bewildering range of functional attributes of these remarkable cells. Until superseded by the proceedings of the fourth Leiden conference (and what a prospect that is!) these two volumes will undoubtedly become the definitive text for anyone interested in mononuclear phagocytes.'
Journal of Clinical Pathology (May 1981)
`For those interested in the occult mysteries and properties of one of the most fascinating but difficult cell series to trace in origin and function, this two-volume series on mononuclear phagocytes will prove exceptionally interesting. It is a relatively complete chronicle of the progress made over the past decade in elucidating the function and stem cell origin of renewing populations of mononuclear phagocytes and related cells. The two volumes will prove useful as references for both teaching and research.'
American Journal of Veterinary Research, 42 (1981)
`These two volumes constitute an important landmark in the study of 'inflammation'. ...well produced and should be of value, not only to cellular pathologists and scientists, but also to all of us concerned with human diseases.'
Journal of the European Society of Pathology (October 1980)

• Department of Infectious Diseases, University Hospital, Leiden, The Netherlands

  Ralph Furth

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