Blood Filtration and Blood Cell Deformability

Summary of the proceedings of the third workshop held in London, 6 and 7 October 1983, under the auspices of the Royal Society of the Medicine and the Groupe de Travail sur la Filtration Erythrocitaire

  • John Dormandy

Part of the Developments in Hematology and Immunology book series (DIHI, volume 12)

Table of contents

  1. Front Matter
    Pages I-X
  2. Introduction and welcome

    1. J. A. Dormandy
      Pages 1-1
  3. Welcome on behalf of the Groupe de Travail sur la Filtration Erythrocytaire

  4. The place of red cell filterability in the microcirculation

  5. Effect of white blood cells on red cell filterability and the measurement of red cell deformability

  6. Preparation of blood samples for filtration studies

  7. Comparison of blood filtration systems with other techniques for assessing red cell deformability

  8. New evidence on possible clinical relevance of blood filtration systems

    1. Front Matter
      Pages 69-69
    2. F. Laghi Pasini
      Pages 73-74
    3. J. A. Dormandy
      Pages 76-77
    4. G. D. O. Lowe
      Pages 85-98
    5. M. Verstraete
      Pages 99-100
    6. P. Gaehtgens
      Pages 101-102

About this book


H. J. Meiselman From the theoretical studies of Dr. Skalak, it is clear that white cells can significantly influence the pressure-time profile of a red cell/white cell suspen­ sion, and that the presence of even a small amount of relatively rigid white cells can have a profound effect on the filtration pressure during the latter portion of a filtration experiment. Conversely, white cell effects, regardless of their relative rigidity, are shown to have only minimal effects during the very early (i. e. , 0-2 seconds) phases of the filtration process. Dr. Chien's experimental data support these theoretical studies, in that white cells of different mechan­ ical properties exhibit different pressure-time curves; pressure-time data for mixtures of leucocytes show shapes which can be predicted from the behavior of relatively homogeneous cell populations. The insensitivity of the very early portions of the filtration process to white cells is again reflected in the calculations made by Dr. Hanss. Using the nominal dilutions, white cell concentrations and the total volume of filtered cell suspension, he indicates that usually less than 1 pore out of 100 is liable to blockage by white cells. He thus concludes that, at the 1% accuracy level, initial filtration data should not be affected by mechanical pore blockage by white cells. Experimental studies by Dr. Lowe and Dr. Stuart question the WBC­ insensitivity of the early portion of the filtration process. Using a constant flow system, Dr.


age behavior blood blood cell cell cells circulation diabetes distribution erythrocyte medicine membrane patients population viscoelastic properties

Editors and affiliations

  • John Dormandy
    • 1
    • 2
  1. 1.St. George’s HospitalLondonUK
  2. 2.St. George’s HospitalLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1985
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-89838-714-8
  • Online ISBN 978-94-009-5008-5
  • Buy this book on publisher's site