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NMR in Living Systems

  • Theodore Axenrod
  • Giulio Ceccarelli

Part of the Nato ASI Series book series (ASIC, volume 164)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Cherie L. Fisk, Edwin D. Becker
    Pages 1-17
  3. Edwin D. Becker, Cherie L. Fisk
    Pages 39-52
  4. Dieter Ziessow
    Pages 95-107
  5. F. De Luca, B. C. De Simone, B. Maraviglia, R. Campanella, C. Casieri
    Pages 109-116
  6. Aldo Rescigno, Charles C. Duncan
    Pages 123-156
  7. Derek Shaw
    Pages 157-168
  8. L. D Hall, W. A. Stewart
    Pages 169-175
  9. L. D. Hall, H. Chow, S. Luck, T. Marcus, C. Neale, B. Powell et al.
    Pages 217-230
  10. Laurel O. Sillerud, James W. Heyser, Chung H. Han, Mark W. Bitensky
    Pages 309-333
  11. L. D. Hall, J. Lee, V. Rajanayagam, L. Talagala
    Pages 367-375
  12. L. D. Hall, W. A. Stewart
    Pages 385-390
  13. Back Matter
    Pages 391-410

About this book

Introduction

In the four decades since its discovery nuclear magnetic resonance (NMR) has become an indispensable tool for obtaining chemical information often. inaccessible by other methods. With the development of instruments of increasingly higher magnetic field strengths, the integration of powerful computers and the availability of an expanding array of flexible software new applications and developments have proliferated rapidly. Among the more exciting new advances is the use of NMR spectroscopy to probe biological systems. The last ten years have witnessed tremendous progress in the development of new NMR imaging and spectroscopic techniques for research and diagnostic applications. The ability to investigate metabolic processes and anatomical structure of intact biological systems under conditions that are totally non-destructive and non-invasive clearly provides much of the impetus for the intense activity that has been generated in the fields of medicine, radiology and the allied basic sciences. Significant advances have been made in this brief period: Whole-body proton NMR imaging today provides anatomical definition of normal and abnormal tissue with a contrast and detection sensitivity often superior to those of X-ray computed tomography and other competing imaging methods. Biochemical pathways, using NMR spectroscopy of protons, carbon-13 and phosphorus-31 nuclei in live animals and man can readily be followed by surface-coil methods to detect metabolites in localized regions. Indicative of the importance and widespread acceptance of these techniques is the explosive growth that the NMR literature is experiencing. This augers well for the future.

Keywords

X-ray computed tomography computed tomography (CT) diagnosis imaging magnetic resonance radiology tomography

Editors and affiliations

  • Theodore Axenrod
    • 1
  • Giulio Ceccarelli
    • 2
  1. 1.Department of ChemistryCity College of the City University of New YorkUSA
  2. 2.Institute of Physical ChemistryUniversity of PisaItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-4580-7
  • Copyright Information Springer Science+Business Media B.V. 1986
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-8535-9
  • Online ISBN 978-94-009-4580-7
  • Series Print ISSN 1389-2185
  • Buy this book on publisher's site