Pathogenesis and Treatment of Diabetes Mellitus

  • J. K. Radder
  • H. H. P. J. Lemkes
  • H. M. J. Krans

Table of contents

  1. Front Matter
    Pages I-XII
  2. Pathogenesis of Diabetes Mellitus

    1. Type I Diabetes Mellitus

      1. J. K. Radder
        Pages 1-10
      2. P. G. Babu, S. A. Huber, J. E. Graighead
        Pages 11-15
      3. R. B. Tattersall
        Pages 27-32
    2. Type II Diabetes Mellitus

      1. V. Broadstone, W. K. Ward, J. G. Beard, J. D. Best, J. B. Halter, R. Judzewitsch et al.
        Pages 39-57
      2. P. J. Lefebvre, A. S. Luyckx
        Pages 58-62
      3. Tj. Wieringa
        Pages 75-82
  3. Treatment of Diabetes Mellitus

    1. Diet and hypoglycaemic agents

      1. R. G. Josse, A. L. Jenkins, D. J. A. Jenkins
        Pages 91-102
      2. H. Keen, S. Ng Tang Fui
        Pages 103-120
    2. Insulin

      1. J. Terpstra
        Pages 121-122
      2. E. R. Trimble
        Pages 123-130
      3. A. M. Albisser, B. S. Leibel
        Pages 142-151
    3. Pancreas transplantation

      1. H. H. P. J. Lemkes
        Pages 152-155
      2. P. McMaster, W. A. Jurewics, B. H. Gunson, R. M. Kirby
        Pages 156-165
  4. Back Matter
    Pages 167-172

About this book


In this book on diabetes mellitus both the pathogenesis and treat­ ment of the disease will be discussed. Pathogenetic studies have led to the distinction between type I and type II diabetes. In type I hyperglycaemia is due predominantly to insulin deficiency; in type II insulin resistance is more important. Three pathogenetic factors are thought to play a role in the etiol­ ogy of type I diabetes: heredity, viral infections and immunity. There may be a relationship between these three aspects since genetic pre­ disposition changes the susceptibility to viral infections and/or the immunological defence against these infections. Insulitis ensues. Auto­ immune processes initiated by this chain of events may contribute to the destruction of the B cells in the islets of Langerhans and diabetes -may eventually follow. This means that at the time of the sudden out­ break of the disease, the destructive process has already been active for years.


Diabetes Diabetes mellitus Insulin Pancreas Viral Diabetes

Editors and affiliations

  • J. K. Radder
    • 1
  • H. H. P. J. Lemkes
    • 1
  • H. M. J. Krans
    • 1
  1. 1.Department of Endocrinology and MetabolismLeiden University HospitalLeidenThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1986
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-8411-6
  • Online ISBN 978-94-009-4301-8
  • Buy this book on publisher's site