The Role of Pharmacology in Pediatric Oncology

  • D. G. Poplack
  • L. Massimo
  • P. Cornaglia-Ferraris

Part of the Developments in Oncology book series (DION, volume 44)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Principles of antineoplastic therapy in children

    1. Front Matter
      Pages 1-1
    2. William E. Evans, Clinton F. Stewart, Michael L. Christensen, William R. Crom
      Pages 29-71
  3. Pharmacologic reasons for treatment failure

    1. Front Matter
      Pages 73-73
    2. Vassilios Avramis, Robert Biener, John Holcenberg
      Pages 97-112
  4. Methods of drug delivery

    1. Front Matter
      Pages 113-113
    2. Solomon Zimm, David G. Poplack
      Pages 115-123
    3. Jerry M. Collins
      Pages 125-135
    4. David G. Poplack, Riccardo Riccardi
      Pages 137-156
  5. Use of new agents in children

    1. Front Matter
      Pages 157-157
    2. Richard S. Ungerleider, Silvia Marsoni
      Pages 159-170
  6. Pharmacology of antileukemic agents

    1. Front Matter
      Pages 177-177
    2. Riccardo Riccardi, Anna Lasorella, Renato Mastrangelo
      Pages 179-184
    3. Jos P. M. Bökkerink, Ronney A. De Abreu, Marinka A. H. Bakker, Tilly W. Hulscher
      Pages 185-191
  7. Late effects of chemotherapy

    1. Front Matter
      Pages 205-205
    2. L. Massimo, M. L. Garre, S. Gandus, B. Cesana, R. Haupt, B. de Bernardi et al.
      Pages 217-233
  8. High dose chemotherapy

    1. Front Matter
      Pages 235-235
    2. Thierry Philip, Marie Favrot, Irene Philip, Pierre Biron, Ross Pinkerton
      Pages 237-253
    3. G. Dini, D. Rogers, A. Garaventa, E. Lanino, G. P. Perin, M. Stura et al.
      Pages 255-261
  9. Biological response modifiers

    1. Front Matter
      Pages 263-263
    2. A. Giner-Sorolla, J. W. Hadden
      Pages 275-284
    3. Carlo Riccardi, Graziella Migliorati, Antonio Giampietri, Lorenza Cannarile, Emira Ayroldi, Luigi Frati
      Pages 303-307
    4. C. Grandori, G. Graziani, C. F. Perno, C. D’onofrio, E. Bonmassar
      Pages 309-319
  10. Back Matter
    Pages 321-322

About this book


The dramatic improvement made in recent years in the treatment of child­ hood malignancies has been in large part the result of advances in the field of pharmacology. Chemotherapy is the major therapeutic modality used to treat childhood cancer. Rational administration of antineoplastic chemo­ therapy to the child with cancer requires the pediatric oncologist to have a thorough understanding of the fundamental principles of clinical pharmaco­ logy, an intimate knowledge of the specific agents being used, and an aware­ ness of the unique biologic and physiologic features of children. In mid 1985, a distinguished group of pediatric oncologists and clinical pharmacologists convened in a unique workshop to review the subject of pharmacology in pediatric oncology. A goal of this workshop was to pro­ duce a book which would review this topic and present it in a format useful for the clinician. In this book basic principles of pharmacology, mechanisms of drug resis­ tance, new methods of drug delivery, guidelines for studying new agents in children, new biological response modifiers and the pharmacology of the most commonly used chemotherapeutic agents in children are reviewed in depth. Particular emphasis is given to discussing those topics which unique­ ly apply to the use of antineoplastic agents in children with cancer. The Editors VII Contents Preface . v Contents Vll List of Major Contributors Xl Principles of Antineoplastic Therapy in Children 1. Clinical pharmacokinetics for the pediatric oncologist ................ .


cancer cell chemotherapy drug drug delivery drug resistance kinetics leukemia lymphoma pharmacokinetics pharmacology research resistance transplantation

Editors and affiliations

  • D. G. Poplack
    • 1
  • L. Massimo
    • 2
  • P. Cornaglia-Ferraris
    • 2
  1. 1.Leukemia Biology Section, Pediatric BranchNational Institutes of HealthBethesdaUSA
  2. 2.Istituto Giannina GasliniGenovaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1987
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-8395-9
  • Online ISBN 978-94-009-4267-7
  • Buy this book on publisher's site