Application of Monoclonal Antibodies in Tumor Pathology

  • Dirk J. Ruiter
  • Gert Jan Fleuren
  • Sven O. Warnaar

Part of the Developments in Oncology book series (DION, volume 50)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Basic and Technical Aspects

    1. Front Matter
      Pages 1-1
    2. S. O. Warnaar
      Pages 3-21
    3. F. T. Bosman
      Pages 23-36
    4. H. Mullink, D. M. Boorsma, S. C. Henzen-Logmans, C. J. L. M. Meijer
      Pages 37-47
  3. Tumor Associated Antigens

    1. Front Matter
      Pages 49-49
    2. F. C. S. Ramaekers, A. Huijsmans, G. Schaart, O. Moesker, G. P. Vooijs
      Pages 65-85
    3. D. J. Ruiter, E-B. Broecker, C. Vennegoor, S. Ferrone
      Pages 131-165
    4. Ph. C. Hageman, J. L. Peterse, J. Hilkens, J. Hilgers
      Pages 167-190
    5. L. De Leij, J. Broers, F. Ramaekers, H. Berendsen, Sj. Sc. Wagenaar
      Pages 191-210
    6. J. W. Arends, T. Wiggers, C. P. H. J. Verstijnen, F. T. Bosman
      Pages 211-222
    7. G. J. Fleuren
      Pages 237-254
    8. A. C. Nieuwenhuijzen Kruseman
      Pages 255-263
    9. G. P. Vooijs, A. C. L. M. Huysmans, M. H. J. Salet-V. D. Pol, A. J. M. Aspert-Van Erp, F. C. S. Ramaekers
      Pages 265-281
    10. A. Thor, N. Ohuchi, P. Horan Hand, M. O. Weeks, W. W. Johnston, C. A. Szpak et al.
      Pages 283-296
  4. Practical Application and Case Presentations

    1. Front Matter
      Pages 297-297
    2. C. J. L. M. Meijer, R. Willemze, S. C. Henzen-Logmans, H. Mullink
      Pages 319-326
    3. S. C. Henzen-Logmans, C. J. L. M. Meijer
      Pages 327-331
    4. D. J. Ruiter, A. H. M. Taminiau
      Pages 333-338
    5. D. J. Ruiter, W. V. Dolsma
      Pages 339-343
    6. D. J. Ruiter, A. H. M. Taminiau
      Pages 345-350
    7. S. C. Henzen-Logmans, W. F. M. Strankinga, H. Mullink, C. J. L. M. Meijer
      Pages 351-356
    8. G. J. Fleuren, C. V. D. Berg, O. A. M. Langezaal
      Pages 357-360
    9. J. R. J. Elbers, Sj. Sc. Wagenaar, J. K. Th. M. Aumann, J. M. N. Van Den Bosch
      Pages 367-373
  5. Back Matter
    Pages 375-391

About this book


The development of monoclonal antibodies to human tumor associated antigens has greatly facilitated the application of immunohistochemical techniques to analyze surgically removed tissues. During the last few years this approach has been utilized by a progressively increasing number of investigators to analyze malignant cells. Although monoclonal antibodies to tumor associated antigens have not become yet routine reagents in immunopathology, they have provided new information which could not be obtained with conventional antisera or histochemical procedures. The following are representative examples. TUmor associated antigens have been identified which display a restricted distribution in normal tissues and therefore may represent useful markers for radio­ imaging and appropriate targets for immunotherapy. In spite of undetec­ table differences with conventional histopathological approaches hetero­ geneity has been found in the antigenic profile of tumor cells within a lesion, in autologous lesions removed from different anatomic sites from a given patient and in lesions removed from different patients. Phenotypes of tumor cells have been identified which correlate with the biology of tumor cells and with the clinical course of the disease. From a practical view point the use of monoclonal antibodies in immunopathology has enhanced interactions between pathologists and immunologists, as exemplified by the present book. Such interactions have contributed to the application of basic research to clinical problems. The chapter of this book discuss investigations performed with monoclonal antibodies to antigens expressed by various types of normal and malignant human cells.


Antigen antibody carcinoma cell classification histopathology liver lymphoma melanoma mesothelioma oncogene ovarian cancer pathology proteins tumor

Editors and affiliations

  • Dirk J. Ruiter
    • 1
  • Gert Jan Fleuren
    • 2
  • Sven O. Warnaar
    • 2
  1. 1.Department of PathologyUniversity Medical CenterNijmegenThe Netherlands
  2. 2.Department of PathologyUniversity Medical CenterLeidenThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1987
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-7981-5
  • Online ISBN 978-94-009-3299-9
  • Buy this book on publisher's site