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LHRH and Its Analogs

Contraceptive and Therapeutic Applications Part 2

  • Editors
  • B. H. Vickery
  • J. J. NestorJr.

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Chemistry

    1. Front Matter
      Pages 1-1
    2. J. J. Nestor Jr
      Pages 3-16
    3. R. W. Roeske, N. C. Chaturvedi, T. Hrinyo-Pavlina, M. Kowalczuk
      Pages 17-24
    4. K. Folkers, C. Bowers, P.-F. L. Tang, D. Feng, T. Okamoto, Y. Zhang et al.
      Pages 25-36
    5. K. Nikolics, P. H. Seeburg
      Pages 37-51
    6. J. A. King, R. P. Millar
      Pages 53-73
  3. Mechanisms of Action of Hypothalamic LHRH and Analogs

    1. Front Matter
      Pages 75-75
    2. C. A. McArdle, P. M. Conn
      Pages 77-100
  4. Extra-Hypothalamic LHRH-Like Materials

    1. Front Matter
      Pages 121-121
    2. T. A. Bramley
      Pages 123-139
    3. M. P. Hedger, D. M. Robertson, D. M. de Kretser
      Pages 141-160
    4. T. M. Siler-Khodr
      Pages 161-175
  5. Pharmacology of LHRH Antagonists

    1. Front Matter
      Pages 177-177
    2. M. J. Karten, W. A. Hook, R. P. Siraganian, D. H. Coy, K. Folkers, J. E. River et al.
      Pages 179-190
    3. A. Phillips, D. W. Hahn, C. Bishop, R. J. Capetola, J. L. McGuire
      Pages 191-200
  6. Basic Clinical Studies

    1. Front Matter
      Pages 243-243
    2. S. N. Pavlou, G. B. Wakefield, W. J. Kovacs
      Pages 245-256
    3. S. E. Monroe, J. L. Andreyko, R. B. Jaffe
      Pages 257-277
    4. Z. M. van der Spuy, L. Pillay, F. Hardie, M. van der Watt, T. de Chalain, H. Kaplan et al.
      Pages 293-301
    5. H. S. Jacobs, R. Porter, A. Eshel, I. Craft
      Pages 303-319
  7. Clinical Trials

    1. Front Matter
      Pages 321-321
    2. S. J. Ory
      Pages 323-335
    3. M. R. Henzl, S. E. Monroe
      Pages 337-347
    4. J. L. Kirkland, T. H. Lin
      Pages 349-362
    5. J. Sandow, W. Von Rechenberg
      Pages 363-382
    6. M. B. Garnick, A. Lipton, A. Harvey, D. T. Max, J. A. Smith, L. M. Glodes
      Pages 383-395
    7. R. J. Donnelly, R. A. V. Milsted
      Pages 397-409
    8. S. Bhasin, B. S. Steiner, R. S. Swerdloff
      Pages 427-439
  8. Gonadal Protective Prospects with LHRH Analogs

  9. Diagnostic Applications

    1. Front Matter
      Pages 471-471
  10. Applications in Animals

    1. Front Matter
      Pages 487-487
    2. L. W. Crim, R. E. Peter, G. Van Der Kraak
      Pages 489-498
    3. H. A. Garverick, J. S. Stevenson
      Pages 499-515
    4. B. H. Vickery, G. I. McRae, J. C. Goodpasture
      Pages 517-543
  11. Formulation and Metabolism

    1. Front Matter
      Pages 545-545
    2. R. L. Chan, C. A. Nerenberg
      Pages 577-593
  12. Epilogue

    1. B. H. Vickery, J. J. Nestor Jr.
      Pages 595-603
  13. Back Matter
    Pages 605-614

About this book

Introduction

Since the discovery of LHRH in 1971, research into the physiology and therapeutics of this compound can be divided into three dis­ tinctly different phases. In the first phase, attention was paid chiefly to the natural sequence hormone; efforts were channeled to explore its diagnostic use; and nearly all the clinical investigations were coordinated by a single pharmaceutical company. The successes in this area were quite limited and the interest in the promise of this agent as a diagnostic test has long since waned. This phase of research con­ sumed roughly the first seven years of clinical testing after the isolation and characterization of the compound by the two groups involved in the Nobel effort. With the appearance of long-acting LHRH agonists, the second phase of research on LHRH began in the late '70's. LHRH agonists were the only compounds available during this period of research and paradoxical desensitization was the predominant therapeutic basis for the discoveries. An ever-widening number of therapeutic applications using this approach were unearthed. A second theme which emerged during this second 5-7 year period was that the pulsatile administration of the natural sequence LHRH could be used to treat LHRH deficiency in men and women.

Keywords

contraception fertility hormones placenta

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-3229-6
  • Copyright Information Springer Science+Business Media B.V. 1987
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-7949-5
  • Online ISBN 978-94-009-3229-6
  • Buy this book on publisher's site